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pKa tuning in quadrupolar-type two-photon ratiometric fluorescent membrane probes

Abstract : Two bolaamphiphilic quadrupoles built from a fluorene core conjugated with azine endgroups were designed and successfully used to stain GUV membranes. Their quadrupolar character induces both a shift of the pKa values close to the physiological pH and large two-photon absorption responses (i.e. over 1000 GM for acidic forms). As such they hold promise as ratiometric two-photon pH probes for monitoring slight variations of pH near cell membranes using two-photon excitation in the NIR region
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01231149
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Submitted on : Wednesday, December 2, 2015 - 3:21:47 PM
Last modification on : Friday, March 6, 2020 - 11:36:22 AM
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Jonathan Daniel, Cristiano Mastrodonato, Aude Sourdon, Guillaume Clermont, Jean-Marie Vabre, et al.. pKa tuning in quadrupolar-type two-photon ratiometric fluorescent membrane probes. Chemical Communications, Royal Society of Chemistry, 2015, 51 (83), pp.15245--15248. ⟨10.1039/C5CC04573H⟩. ⟨hal-01231149⟩

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