Vicinal α,β-Functionalizations of Amines: Cyclization Versus Dehydrogenative Hydrolysis
Abstract
Direct vicinal α,β-difunctionalization of tertiary cyclic amines is achieved in the presence of ruthenium or iridium transition-metal complexes featuring phosphine-sulfonate chelates. By varying the reaction conditions, α-alkylated lactams were obtained by a formal dehydrogenative hydrolysis in which one molecule of hydrogen is generated from water.
Origin : Files produced by the author(s)