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Vicinal α,β-Functionalizations of Amines: Cyclization Versus Dehydrogenative Hydrolysis

Abstract : Direct vicinal α,β-difunctionalization of tertiary cyclic amines is achieved in the presence of ruthenium or iridium transition-metal complexes featuring phosphine-sulfonate chelates. By varying the reaction conditions, α-alkylated lactams were obtained by a formal dehydrogenative hydrolysis in which one molecule of hydrogen is generated from water.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01231155
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Submitted on : Thursday, November 19, 2015 - 3:46:49 PM
Last modification on : Thursday, March 5, 2020 - 2:02:24 PM

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Fan Jiang, Mathieu Achard, Christian Bruneau. Vicinal α,β-Functionalizations of Amines: Cyclization Versus Dehydrogenative Hydrolysis. Chemistry - A European Journal, Wiley-VCH Verlag, 2015, 21 (41), pp.14319--14323. ⟨10.1002/chem.201502431⟩. ⟨hal-01231155⟩

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