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Optimising the diagnosis and the treatment of iron overload diseases

Abstract : A number of human disorders are related to chronic iron overload, either of genetic or acquired origin. The multi-organ damage produced by iron excess leads, in adults and in children, to severe clinical consequences, affecting both quality of life and life expectancy. The diagnosis is increasingly based on a non-invasive strategy, resorting to clinical, biological and imaging data. The treatment rests on either venesection or chelation therapy, depending on the etiology. Major advances in the fields of molecular biology, pharmacology, and biotechnology pave the road for key improvements in the diagnostic and therapeutic management of the patients.
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Submitted on : Thursday, April 28, 2016 - 3:37:43 PM
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Optimising the diagnosis and t...
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Pierre Brissot. Optimising the diagnosis and the treatment of iron overload diseases. Expert Review of Gastroenterology & Hepatology, Future Drugs, 2007-, 2016, 10 (3), pp.359-370. ⟨10.1586/17474124.2016.1119043⟩. ⟨hal-01231411⟩



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