Recent advances in cancer treatment by Iron Chelators

Vincent Corcé (1) , Sébastien G. Gouin (1) , Stéphanie Renaud (2, 3) , François Gaboriau (2) , David Deniaud (1)

1 CEISAM - Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation
2 Foie, métabolismes et cancer
3 SATT OUEST VALORISATION - Société d'Accélération du Transfert de Technologies

The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short description of the importance of iron for cancer cell proliferation, we will review the different iron chelators developed as potential chemotherapeutics. Finally, the recent efforts to vectorize the chelating agents specifically in the microtumoral environment will be discussed in detail

Mots clés: 8-Hydroxyquinoline; Iron; Metal chelators; polyamine; Tumor vectorisation

Domaines: Sciences du Vivant [q-bio]; Cancer

Vincent Corcé, Sébastien G. Gouin, Stéphanie Renaud, François Gaboriau, David Deniaud. Recent advances in cancer treatment by Iron Chelators. Bioorganic and Medicinal Chemistry Letters, 2016, 26 (2), pp.251-256. ⟨10.1016/j.bmcl.2015.11.094⟩. ⟨hal-01237081⟩