1Microbiologie : Risques Infectieux (UFR Sciences Pharmaceutiques et Biologiques, Département de Bactériologie Virologie et Hygiène Hospitalière - 2 avenue du Professeur Léon Bernard (Bât 15) 35043 Rennes - France)
Abstract : Porphyromonas gingivalis is an etiologic agent of periodontal disease in humans. The disease is associated with the formation of a mixed oral biofilm which is exposed to oxygen and environmental stress, such as oxidative stress. To investigate possible roles for cytochrome bd oxidase in the growth and persistence of this anaerobic bacterium inside the oral biofilm, mutant strains deficient in cytochrome bd oxidase activity were characterized. This study demonstrated that the cytochrome bd oxidase of Porphyromonas gingivalis, encoded by cydAB, was able to catalyse O2 consumption and was involved in peroxide and superoxide resistance, and dioxygen tolerance
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01239809
Contributor : Laurent Jonchère
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Submitted on : Tuesday, December 8, 2015 - 11:46:16 AM
Last modification on : Thursday, February 14, 2019 - 4:40:36 PM
Julia Leclerc, Eric Rosenfeld, Mathieu Trainini, Bénédicte Martin, Vincent Meuric, et al.. The Cytochrome bd Oxidase of Porphyromonas gingivalis Contributes to Oxidative Stress Resistance and Dioxygen Tolerance. PLoS ONE, Public Library of Science, 2015, 10 (12), pp.e0143808. ⟨10.1371/journal.pone.0143808⟩. ⟨hal-01239809⟩
