Synthesis of Fluorine-Containing Exoalkylidene β-Lactams

Assaad Nasr El Dine (1) , Danielle Grée (2) , Thierry Roisnel (2) , Elsa Caytan (2) , Ali Hachem (1) , René Grée (2)

1 LU - Lebanese University [Beirut]
2 ISCR - Institut des Sciences Chimiques de Rennes

The Kinugasa reaction, applied to propargylic gem-difluorides, allows a very direct and efficient synthesis of new exoalkylidene β-lactams with a fluorine in the vinylic position

Keywords: Lactams; Fluorine; Alkynes; Nitrones; Small ring systems

Domains: Chemical Sciences

Assaad Nasr El Dine, Danielle Grée, Thierry Roisnel, Elsa Caytan, Ali Hachem, et al.. Synthesis of Fluorine-Containing Exoalkylidene β-Lactams. European Journal of Organic Chemistry, 2016, 2016 (3), pp.556-561. ⟨10.1002/ejoc.201501347⟩. ⟨hal-01242905⟩