Recyclable Organocatalyst-Promoted One-Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers - Archive ouverte HAL Access content directly
Journal Articles Advanced Synthesis and Catalysis Year : 2015

Recyclable Organocatalyst-Promoted One-Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers

Abstract

A recyclable fluorous bifunctional Cinchona alkaloid/thiourea-catalyzed and four-component Michael/Mannich/cyclization sequence has been developed for the asymmetric synthesis of spirooxindoles containing 2-piperidinone and tetrahydropyridine rings. This one-pot reaction process affords the products in good to excellent yields and up to 99% ee and 9:1 dr

Dates and versions

hal-01242906 , version 1 (14-12-2015)

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Xin Huang, Kenny Pham, Wenbin Yi, Xiaofeng Zhang, Cécilia Clamens, et al.. Recyclable Organocatalyst-Promoted One-Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers. Advanced Synthesis and Catalysis, 2015, 357 (18), pp.3820-3824. ⟨10.1002/adsc.201500748⟩. ⟨hal-01242906⟩
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