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Recyclable Organocatalyst-Promoted One-Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers

Abstract : A recyclable fluorous bifunctional Cinchona alkaloid/thiourea-catalyzed and four-component Michael/Mannich/cyclization sequence has been developed for the asymmetric synthesis of spirooxindoles containing 2-piperidinone and tetrahydropyridine rings. This one-pot reaction process affords the products in good to excellent yields and up to 99% ee and 9:1 dr
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01242906
Contributor : Laurent Jonchère <>
Submitted on : Monday, December 14, 2015 - 12:08:41 PM
Last modification on : Friday, July 17, 2020 - 8:32:02 PM

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Xin Huang, Kenny Pham, Wenbin Yi, Xiaofeng Zhang, Cécilia Clamens, et al.. Recyclable Organocatalyst-Promoted One-Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers. Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2015, 357 (18), pp.3820-3824. ⟨10.1002/adsc.201500748⟩. ⟨hal-01242906⟩

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