Recyclable Organocatalyst-Promoted One-Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers
Abstract
A recyclable fluorous bifunctional Cinchona alkaloid/thiourea-catalyzed and four-component Michael/Mannich/cyclization sequence has been developed for the asymmetric synthesis of spirooxindoles containing 2-piperidinone and tetrahydropyridine rings. This one-pot reaction process affords the products in good to excellent yields and up to 99% ee and 9:1 dr