Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines - Archive ouverte HAL Access content directly
Journal Articles SYNLETT Year : 2015

Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines

(1) , (1) , (1) , (2) , (2) , (3) , (3) , (3) , (1)
1
2
3

Abstract

The synthesis of triaryl methanols was investigated by reacting different 4-metalated 2-substituted pyrimidines with diaryl ketones, the latter being generated by deprotocupration-aroylation of azine and diazine substrates. Cyclization of the triaryl methanols thus obtained afforded pyrido[3’,2’:4,5]pyrrolo[1,2-c]pyrimidines, which were evaluated for kinase inhibition and antiproliferative activities in melanoma cells.
Fichier principal
Vignette du fichier
Synlett 2015, 26, 2811-2816.pdf (926.4 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-01248092 , version 1 (04-01-2016)

Identifiers

Cite

Nada Marquise, Tan Tai Nguyen, Floris Chevallier, Laurent Picot, Valérie Thiéry, et al.. Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c] pyrimidines. SYNLETT, 2015, 26 (20), pp.2811-2816. ⟨10.1055/s-0035-1560496⟩. ⟨hal-01248092⟩
154 View
717 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More