Skip to Main content Skip to Navigation
Journal articles

Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors

Abstract : The copper-catalyzed asymmetric conjugate addition (ACA) of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field
Document type :
Journal articles
Complete list of metadata

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01254825
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Wednesday, May 26, 2021 - 10:42:17 AM
Last modification on : Friday, October 22, 2021 - 2:42:40 PM
Long-term archiving on: : Friday, August 27, 2021 - 6:45:10 PM

File

Copper-catalyzed asymmetric co...
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Thibault E. Schmid, Sammy Drissi-Amraoui, Christophe Crévisy, Olivier Baslé, Marc Mauduit. Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors. Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2015, 11, pp.2418--2434. ⟨10.3762/bjoc.11.263⟩. ⟨hal-01254825⟩

Share

Metrics

Record views

187

Files downloads

33