Skip to Main content Skip to Navigation
Journal articles

Functional gastrointestinal disorders and incidence of type 2 diabetes: Evidence from the E3N–EPIC cohort study

Abstract : Objective Functional gastrointestinal disorders (FGID) such as diarrhoea and constipation can reflect intestinal dysfunction, especially with regard to intestinal microbiota, which, in turn, have been associated with chronic conditions, including obesity and insulin resistance. However, little is known of the association between FGID and type 2 diabetes (T2D) risk. Design and methods This analysis aimed to determine the influence of diarrhoea, constipation and alternating bouts of diarrhoea/constipation on T2D risk in 62,683 women from the prospective E3N–EPIC cohort. Results A total of 1795 T2D cases were recorded during follow-up. Compared with women who had normal gastrointestinal transits, women with chronic diarrhoea or alternating diarrhoea/constipation were at increased risk of T2D (HR: 1.29, 95% CI: 1.00–1.65 vs. HR: 1.32, 95% CI: 1.15–1.52, respectively), whereas women with constipation had a decreased risk (HR: 0.67, 95% CI: 0.57–0.78). There was no interaction between FGID and body mass index for risk of T2D. Also, these associations were independent of dietary habits such as coffee, fruit and vegetable consumption, and even of the use of laxatives and psychotropic drugs. Conclusion The present analysis showed, for the first time, a limited association between FGID and T2D risk in a large prospective cohort, and supports the hypothesis of a relationship between gastrointestinal function and diabetes. The presence of gastrointestinal transit disorders may assist in screening for subjects at higher risk of diabetes beyond the conventional risk factors
Document type :
Journal articles
Complete list of metadatas

Cited literature [27 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01255822
Contributor : Laurent Jonchère <>
Submitted on : Thursday, January 14, 2016 - 2:58:48 PM
Last modification on : Sunday, October 25, 2020 - 7:06:43 AM
Long-term archiving on: : Saturday, April 16, 2016 - 10:43:31 AM

File

Functional gastrointestinal di...
Files produced by the author(s)

Identifiers

Citation

G. Fagherazzi, G. Gusto, B. Balkau, M. -C. Boutron-Ruault, F. Clavel-Chapelon, et al.. Functional gastrointestinal disorders and incidence of type 2 diabetes: Evidence from the E3N–EPIC cohort study. Diabetes and Metabolism, Elsevier Masson, 2016, 42 (3), pp.178-183. ⟨10.1016/j.diabet.2015.11.006⟩. ⟨hal-01255822⟩

Share

Metrics

Record views

477

Files downloads

396