T. B. Andersson, K. P. Kanebratt, and J. G. Kenna, tool for understanding drug metabolism and toxicology in human, Expert Opinion on Drug Metabolism & Toxicology, vol.51, issue.5, pp.909-920, 2012.
DOI : 10.1016/j.transproceed.2010.08.064

C. Aninat, A. Piton, D. Glaise, L. Charpentier, T. Langouët et al., EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS, Drug Metabolism and Disposition, vol.34, issue.1, pp.75-83, 2006.
DOI : 10.1124/dmd.105.006759

URL : https://hal.archives-ouvertes.fr/hal-00702085

S. Anthérieu, C. Chesné, R. Li, S. Camus, A. Lahoz et al., Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells, Drug Metabolism and Disposition, vol.38, issue.3, pp.516-525, 2010.
DOI : 10.1124/dmd.109.030197

S. Anthérieu, A. Rogue, B. Fromenty, A. Guillouzo, and M. Robin, Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in heparg cells, Hepatology, vol.96, issue.Suppl., pp.1895-1905, 2011.
DOI : 10.1002/hep.24290

S. Anthérieu, C. Chesné, R. Li, C. Guguen-guillouzo, and A. Guillouzo, Optimization of the HepaRG cell model for drug metabolism and toxicity studies, Toxicology in Vitro, vol.26, issue.8, pp.1278-1285, 2012.
DOI : 10.1016/j.tiv.2012.05.008

S. Anthérieu, P. Bachour-el-azzi, J. Dumont, Z. Abdel-razzak, C. Guguen-guillouzo et al., Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells, Hepatology, vol.35, issue.4, pp.1518-1529, 2013.
DOI : 10.1002/hep.26160

J. Aubert, K. Begriche, L. Knockaert, M. A. Robin, and B. Fromenty, Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role, Clinics and Research in Hepatology and Gastroenterology, vol.35, issue.10, pp.630-637, 2011.
DOI : 10.1016/j.clinre.2011.04.015

URL : https://hal.archives-ouvertes.fr/hal-00739365

S. S. Baker, R. D. Baker, W. Liu, N. J. Nowak, and L. Zhu, Role of Alcohol Metabolism in Non-Alcoholic Steatohepatitis, PLoS ONE, vol.5, issue.3, p.9570, 2010.
DOI : 10.1371/journal.pone.0009570.t005

S. Bansal, H. K. Anandatheerthavarada, G. K. Prabu, G. L. Milne, M. V. Martin et al., Human Cytochrome P450 2E1 Mutations That Alter Mitochondrial Targeting Efficiency and Susceptibility to Ethanol-induced Toxicity in Cellular Models, Journal of Biological Chemistry, vol.288, issue.18, 2013.
DOI : 10.1074/jbc.M113.452367

C. W. Barker, J. B. Fagan, and D. S. Pasco, Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress, J. Biol. Chem, vol.269, pp.3985-3990, 1994.

S. M. Bartlett and G. F. Gibbons, Short- and longer-term regulation of very-low-density lipoprotein secretion by insulin, dexamethasone and lipogenic substrates in cultured hepatocytes. A biphasic effect of insulin, Biochemical Journal, vol.249, issue.1, pp.37-43, 1988.
DOI : 10.1042/bj2490037

K. Begriche, J. Massart, M. A. Robin, F. Bonnet, and B. Fromenty, Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease, Hepatology, vol.6, issue.4, pp.1497-1507, 2013.
DOI : 10.1002/hep.26226

URL : https://hal.archives-ouvertes.fr/inserm-00814080

M. Biour, B. Salem, C. Chazouillères, O. Grangé, J. D. Serfaty et al., H??patotoxicit?? des m??dicaments 14e mise ?? jour du fichier bibliographique des atteintes h??patiques et des m??dicaments responsables, Gastroent??rologie Clinique et Biologique, vol.28, issue.8-9, pp.720-759, 2004.
DOI : 10.1016/S0399-8320(04)95062-2

E. Björnsson, The Natural History of Drug-Induced Liver Injury, Seminars in Liver Disease, vol.29, issue.04, pp.357-363, 2009.
DOI : 10.1055/s-0029-1240004

M. J. Brill, J. Diepstraten, A. Van-rongen, S. Van-kralingen, J. N. Van-den-anker et al., Impact of Obesity on Drug Metabolism and Elimination in Adults and Children, Clinical Pharmacokinetics, vol.21, issue.6, pp.277-304, 2012.
DOI : 10.2165/11599410-000000000-00000

M. J. Canet, M. D. Merrell, R. N. Hardwick, A. M. Bataille, S. N. Campion et al., intestinal glucose absorption and activating hepatic lipogenesis, Br. J. Pharmacol, vol.165, pp.1361-1374

M. R. Mcgill and H. Jaeschke, Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis, Pharmaceutical Research, vol.117, issue.9, pp.2174-2187, 2013.
DOI : 10.1007/s11095-013-1007-6

M. R. Mcgill, H. M. Yan, A. Ramachandran, G. J. Murray, D. E. Rollins et al., HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity, Hepatology, vol.28, issue.3, pp.974-982, 2011.
DOI : 10.1002/hep.24132

M. R. Mcgill, M. Lebofsky, H. R. Norris, M. H. Slawson, M. L. Bajt et al., Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose???response, mechanisms, and clinical implications, Toxicology and Applied Pharmacology, vol.269, issue.3, pp.240-249, 2013.
DOI : 10.1016/j.taap.2013.03.026

A. Michaut, C. Moreau, M. A. Robin, and B. Fromenty, Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease, Liver International, vol.36, issue.Suppl 2, pp.171-179, 2014.
DOI : 10.1111/liv.12514

URL : https://hal.archives-ouvertes.fr/hal-01128195

G. A. Michelotti, M. V. Machado, and A. M. Diehl, NAFLD, NASH and liver cancer, Nature Reviews Gastroenterology & Hepatology, vol.16, issue.11, pp.656-665, 2013.
DOI : 10.6061/clinics/2013(03)OA02

M. E. Miquilena-colina, E. Lima-cabello, S. Sanchez-campos, M. V. Garcia-mediavilla, M. Fernandez-bermejo et al., Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C, Gut, vol.60, issue.10, pp.1394-1402, 2011.
DOI : 10.1136/gut.2010.222844

A. Moncion, N. T. Truong, A. Garrone, P. Beaune, R. Barouki et al., Identification of a 16-Nucleotide Sequence That Mediates Post-transcriptional Regulation of Rat CYP2E1 by Insulin, Journal of Biological Chemistry, vol.277, issue.48, pp.45904-45910, 2002.
DOI : 10.1074/jbc.M207841200

R. P. Myers and A. A. Shaheen, Hepatitis C, alcohol abuse, and unintentional overdoses are risk factors for acetaminophen-related hepatotoxicity, Hepatology, vol.7, issue.4, pp.1399-1400, 2009.
DOI : 10.1002/hep.22798

Y. Xie, M. R. Mcgill, K. Dorko, S. C. Kumer, T. M. Schmitt et al., Mechanisms of acetaminophen-induced cell death in primary human hepatocytes, Toxicology and Applied Pharmacology, vol.279, issue.3, 2014.
DOI : 10.1016/j.taap.2014.05.010

H. Zaher, J. T. Buters, J. M. Ward, M. K. Bruno, A. M. Lucas et al., Protection against Acetaminophen Toxicity in CYP1A2 and CYP2E1 Double-Null Mice, Toxicology and Applied Pharmacology, vol.152, issue.1, pp.193-199, 1998.
DOI : 10.1006/taap.1998.8501

V. A. Zammit, I. J. Waterman, D. Topping, and G. Mckay, Insulin stimulation of hepatic triacylglycerol secretion and the etiology of insulin resistance, J. Nutr, vol.131, pp.2074-2077, 2001.