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Should we fear tubing adsorption of antibacterial drugs in extracorporeal membrane oxygenation? An answer for cephalosporins and carbapenems

Abstract : Extracorporeal membrane oxygenation (ECMO) procedure used in the management of patients with cardiac and/or respiratory failure could modify drugs pharmacokinetics (PK) properties. Studying the impact of ECMO devices on drugs PK is warranted to optimize dosage and ensure clinical outcomes. We aimed to characterize the behavior of four cephalosporins and three carbapenems commonly used in an ECMO circuit with an in-vitro approach focusing on the coated tubing, support of the extracorporeal circulation. Results suggest that these antibiotics are not sequestrated by ECMO tubing. This pilot mechanistic study provides original data that will contribute to improve our understanding of the impact of ECMO on the PK of drugs commonly used in intensive care unit patients.
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Submitted on : Monday, February 8, 2016 - 4:44:05 PM
Last modification on : Thursday, June 18, 2020 - 9:29:17 AM

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Camille Tron, Cyril Leven, Pierre Fillâtre, Nicolas Maillard, Nicolas Nesseler, et al.. Should we fear tubing adsorption of antibacterial drugs in extracorporeal membrane oxygenation? An answer for cephalosporins and carbapenems. Clinical and Experimental Pharmacology and Physiology, Wiley, 2016, 43 (2), pp.281-283. ⟨10.1111/1440-1681.12527⟩. ⟨hal-01255854⟩

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