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Occupational radiation exposure of medical staff performing (90)Y-loaded microsphere radioembolization

Abstract : PURPOSE: Radioembolization of liver cancer with (90)Y-loaded microspheres is increasingly used but data regarding hospital staff exposure are scarce. We evaluated the radiation exposure of medical staff while preparing and injecting (90)Y-loaded glass and resin microspheres especially in view of the increasing use of these products. METHODS: Exposure of the chest and finger of the radiopharmacist, nuclear medicine physician and interventional radiologist during preparation and injection of 78 glass microsphere preparations and 16 resin microsphere preparations was monitored. Electronic dosimeters were used to measure chest exposure and ring dosimeters were used to measure finger exposure. RESULTS: Chest exposure was very low for both products used (\textless10 μSv from preparation and injection). In our experience, finger exposure was significantly lower than the annual limit of 500 mSv for both products. With glass microspheres, the mean finger exposure was 13.7 ± 5.2 μSv/GBq for the radiopharmacist, and initially 17.9 ± 5.4 μSv/GBq for the nuclear medicine physician reducing to 13.97 ± 7.9 μSv/GBq with increasing experience. With resin microspheres, finger exposure was more significant: mean finger exposure for the radiopharmacist was 295.1 ± 271.9 μSv/GBq but with a reduction with increasing experience to 97.5 ± 35.2 μSv/GBq for the six most recent dose preparations. For administration of resin microspheres, the greatest mean finger exposure for the nuclear medicine physician (the most exposed operator) was 235.5 ± 156 μSv/GBq. CONCLUSION: Medical staff performing (90)Y-loaded microsphere radioembolization procedures are exposed to safe levels of radiation. Exposure is lower than that from treatments using (131)I-lipiodol. The lowest finger exposure is from glass microspheres. With resin microspheres finger exposure is acceptable but could be optimized in accordance with the ALARA principle, and especially in view of the increasing use of radioembolization
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01255872
Contributor : Laurent Jonchère <>
Submitted on : Thursday, January 14, 2016 - 9:59:08 AM
Last modification on : Monday, November 30, 2020 - 1:44:59 PM

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Sophie Laffont, Yan Rolland, Valérie Ardisson, Julien Edeline, Marc Pracht, et al.. Occupational radiation exposure of medical staff performing (90)Y-loaded microsphere radioembolization. European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2016, 43 (5), pp.824-831. ⟨10.1007/s00259-015-3277-1⟩. ⟨hal-01255872⟩

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