Skip to Main content Skip to Navigation
Journal articles

Comparison between liposomal formulations of amphotericin B

Abstract : Given the clinical success of commercial amphotericin B lipid products, investigators have begun making generic formulations of liposomal amphotericin B. Generic medicines are an attractive approach to help decrease the cost and accessibility to healthcare, provided that appropriate studies are performed to ensure bioequivalence with the parent product. This is of particular concern for liposomal drugs such as amphotericin B where liposomes are used as a carrier system to reduce the toxicity of the active agent. A favorable therapeutic profile for this form of the drug has to include the proper chemical composition along with strictly controlled manufacturing processes. Studies have shown that a comparison of liposomal amphotericin B products with different or the same chemical compositions, using different methods of production, will vary in size, and have significantly dissimilar in vitro and in vivo toxicities along with reduced efficacy. These results underscore the importance of establishing appropriate bioequivalence testing for liposome products to ensure uniformity of their therapeutic index
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259233
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, January 20, 2016 - 10:26:02 AM
Last modification on : Tuesday, March 3, 2020 - 5:05:26 PM

Links full text

Identifiers

Citation

Jill P. Adler-Moore, Jean-Pierre Gangneux, Peter G Pappas. Comparison between liposomal formulations of amphotericin B. Medical Mycology, Oxford University Press, 2016, 54 (2), pp.223-231. ⟨10.1093/mmy/myv111⟩. ⟨hal-01259233⟩

Share

Metrics

Record views

193