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Aurora A's Functions During Mitotic Exit: The Guess Who Game

Abstract : Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstrated due to the technical difficulty to perform the appropriate experiments. Recent developments of both an analog-specific version of Aurora A and small molecule inhibitors have led to the first demonstration that Aurora A is required for the early steps of cytokinesis. As in pre-metaphase, Aurora A plays diverse functions during anaphase, essentially participating in astral microtubules dynamics and central spindle assembly and functioning. The present review describes the experimental systems used to decipher new functions of Aurora A during late mitosis and situate these functions into the context of cytokinesis mechanisms
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Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Wednesday, January 20, 2016 - 10:26:04 AM
Last modification on : Thursday, January 14, 2021 - 11:20:43 AM

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David Reboutier, Christelle Benaud, Claude Prigent. Aurora A's Functions During Mitotic Exit: The Guess Who Game. Frontiers in Oncology, Frontiers, 2015, 5, pp.290. ⟨10.3389/fonc.2015.00290⟩. ⟨hal-01259234⟩



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