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New mannose derivatives: The tetrazole analogue of mannose-6-phosphate as angiogenesis inhibitor

Abstract : Two novel compounds with mannose-derived structure, bearing a tetrazole (compound 3) and a sulfone group (compound 4) in terminal position, have been prepared from methyl α-D-mannopyranoside in reduced number of steps. The angiogenic activity of 3 and 4 has been screened using the chick chorioallantoic membrane (CAM) method. Tetrazole 3 has been identified to possess a promising bioactivity, being identified as angiogenesis inhibitor, with 68% of neovascular vessels when compared to control (PBS).
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Submitted on : Friday, January 22, 2016 - 2:17:16 PM
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Cătălina Ionescu, Simona Sippelli, Loic Toupet, Véronique Barragan-Montero. New mannose derivatives: The tetrazole analogue of mannose-6-phosphate as angiogenesis inhibitor. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26 (2), pp.636-639. ⟨10.1016/j.bmcl.2015.11.059⟩. ⟨hal-01259520⟩

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