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Journal articles
New mannose derivatives: The tetrazole analogue of mannose-6-phosphate as angiogenesis inhibitor
Abstract : Two novel compounds with mannose-derived structure, bearing a tetrazole (compound 3) and a sulfone group (compound 4) in terminal position, have been prepared from methyl α-D-mannopyranoside in reduced number of steps. The angiogenic activity of 3 and 4 has been screened using the chick chorioallantoic membrane (CAM) method. Tetrazole 3 has been identified to possess a promising bioactivity, being identified as angiogenesis inhibitor, with 68% of neovascular vessels when compared to control (PBS).
Cited literature [13 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259520
Contributor : Laurent Jonchère <>
Submitted on : Friday, January 22, 2016 - 2:17:16 PM
Last modification on : Tuesday, April 13, 2021 - 2:20:02 PM
Long-term archiving on: : Saturday, April 23, 2016 - 10:47:32 AM
Contributor : Laurent Jonchère <>
Submitted on : Friday, January 22, 2016 - 2:17:16 PM
Last modification on : Tuesday, April 13, 2021 - 2:20:02 PM
Long-term archiving on: : Saturday, April 23, 2016 - 10:47:32 AM
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