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In vivo MR spectroscopy of human breast tissue: quantification of fatty acid composition at a clinical field strength (3 T)

Abstract : OBJECTIVE: To evaluate the feasibility of in vivo measurement of the fatty acid (FA) composition of breast adipose tissue by MRS on a clinical platform. MATERIAL AND METHODS: MRS experiments were performed at 3 T, using a STEAM sequence, on 25 patients diagnosed with breast cancer. MR spectra, acquired on healthy breast tissue, were analysed with the LCModel. RESULTS: The measured values of the saturated fatty acid (SFA), mono-unsaturated fatty acid (MUFA) and poly-unsaturated fatty acid (PUFA) fractions were 23.8 ± 7.1 %, 55.4 ± 6.8 % and 20.8 ± 4.4 %, respectively. The values of SFA, MUFA and PUFA observed in the current study are in the same range as those found in two previous studies performed at 7 T. CONCLUSION: The results of the current study show that it is possible to quantify the fatty acid composition of breast tissue in vivo in a clinical setting (3 T)
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01260235
Contributor : Laurent Jonchère <>
Submitted on : Thursday, January 21, 2016 - 5:17:04 PM
Last modification on : Wednesday, January 29, 2020 - 2:41:45 PM

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Amandine Coum, Lobna Ouldamer, Fanny Noury, Laurent Barantin, Aymeric Saint-Hilaire, et al.. In vivo MR spectroscopy of human breast tissue: quantification of fatty acid composition at a clinical field strength (3 T). Magnetic Resonance Materials in Physics, Biology and Medicine, Springer Verlag, 2016, 29 (1), pp.1-4. ⟨10.1007/s10334-015-0506-3⟩. ⟨hal-01260235⟩

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