Skip to Main content Skip to Navigation
Journal articles

Discriminant nonnegative matrix factorization for classification of rectal bleeding in prostate cancer radiotherapy

Abstract : External beam radiotherapy is one of the standard treatments for prostate cancer. Despite advanced radiotherapy techniques allowing precise dose delivery on cancer targets, efficiency of the treatment is limited by the risk of side-effects due to the irradiation to the surrounding organs. Characterizing the local dose–toxicity relationship is crucial to provide new recommendations for treatment planning. Standing on a voxel wise analysis, in this paper we proposed a new method, named Discriminant Nonnegative Matrix Factorization (DNMF), for classifying patients at risk of presenting rectal bleeding. Comparative studies with a classical Nonnegative Matrix Factorization (NMF) algorithm and principal component analysis (PCA) based method are also given. The features extracted by the proposed method for different rank values are used to classify the planned dose distribution images into rectal-bleeding and non-rectal-bleeding. The sensitivity and specificity obtained on 118 patients ( Se = 0.77 and Sp = 0.82 ) show the DNMF as a promising method for predicting the toxicity-related side-effect in the rectum following prostate radiotherapy
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01260599
Contributor : Laurent Jonchère <>
Submitted on : Friday, January 22, 2016 - 1:55:43 PM
Last modification on : Monday, July 20, 2020 - 10:42:06 AM

Identifiers

Citation

L. H. Liu, Amar Kachenoura, A. Fargeas, G. Dréan, C. Lafond, et al.. Discriminant nonnegative matrix factorization for classification of rectal bleeding in prostate cancer radiotherapy. Innovation and Research in BioMedical engineering, Elsevier Masson, 2015, 36 (6), pp.355-360. ⟨10.1016/j.irbm.2015.10.001⟩. ⟨hal-01260599⟩

Share

Metrics

Record views

199