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Nephrectomy improves overall survival in patients with metastatic renal cell carcinoma in cases of favorable MSKCC or ECOG prognostic features

Romain Mathieu 1 Géraldine Pignot 2 Alexandre Ingles 2 Maxime Crépel 1 Pierre Bigot 3 Jean-Christophe Bernhard 4 Florence Joly 5, 6 Laurent Guy 7 Alain Ravaud 8 Abdel Rahmene Azzouzi 3 Gwenaëlle Gravis 9 Christine Chevreau 10 Laurent Zini 11 Hervé Lang 12 Christian Pfister 13 Eric Lechevallier 14 Pierre-Olivier Fais 14 Julien Berger 15 Bertrand Vayleux 16 Morgan Rouprêt 17 François Audenet 18 Aurélien Descazeaud 19 Jérôme Rigaud 16 Jean-Pascal Machiels 20 Michael Staehler 21 Laurent Salomon 22, 23 Jean-Marie Ferrière 4 François Kleinclauss 24, 25 Karim Bensalah 26, 27 Jean-Jacques Patard 28 
Abstract : Objectives : The role of cytoreductive nephrectomy (CN) in the treatment of patients harboring metastatic renal cell carcinoma (mRCC) has become controversial since the emergence of effective targeted therapies. The aim of our study was to compare the overall survival (OS) between CN and non-CN groups of patients presenting with mRCC in the era of targeted drugs and to assess these outcomes among the different Memorial Sloan-Kettering Cancer Center (MSKCC) and The Eastern Cooperative Oncology Group (ECOG) performance status subgroups. Methods and materials A total of 351 patients with mRCC at diagnosis recruited from 18 tertiary care centers who had been treated with systemic treatment were included in this retrospective study. OS was assessed by the Kaplan-Meier method according to the completion of a CN. The population was subsequently stratified according to MSKCC and ECOG prognostic groups. Results Median OS in the entire cohort was 37.1 months. Median OS was significantly improved for patients who underwent CN (16.4 vs. 38.1 months, P<0.001). However, subgroup analysis demonstrated that OS improvement after CN was only significant among the patients with an ECOG score of 0 to 1 (16.7 vs. 43.3 months, P = 0.03) and the group of patients with good and intermediate MSKCC score (16.8 vs. 42.4 months, P = 0.02). On the contrary, this benefit was not significant for the patients with an ECOG score of 2 to 3 (8.0 vs. 12.6 months, P = 0.8) or the group with poor MSKCC score (5.2 vs. 5.2, P = 0.9). Conclusions CN improves OS in patients with mRCC. However, this effect does not seem to be significant for the patients in ECOG performance status groups of 2 to 3 or poor MSKCC prognostic group
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Submitted on : Friday, January 22, 2016 - 2:39:30 PM
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Romain Mathieu, Géraldine Pignot, Alexandre Ingles, Maxime Crépel, Pierre Bigot, et al.. Nephrectomy improves overall survival in patients with metastatic renal cell carcinoma in cases of favorable MSKCC or ECOG prognostic features. Urologic Oncology: Seminars and Original Investigations, Elsevier, 2015, 33 (8), pp.339.e9-339.e15. ⟨10.1016/j.urolonc.2015.05.014⟩. ⟨hal-01260654⟩



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