Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Siwar Mosbahi (1, 2) , Hassane Oudadesse (1) , Bertand Lefeuvre (1) , Allal Barroug (3) , Hafed Elfeki (4) , Abdelfattah Elfeki (4) , Claire Roiland (1) , Hassib Keskes (2)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 Service d'orthopédie, CHU Habib Bouguiba, Sfax, Tunisie.
3 UCA - Université Cadi Ayyad [Marrakech]
4 Faculté des Sciences de Sfax

The aim of the current work is to study the physicochemical interactions between bisphosphonates molecules, risedronate (RIS) and bioactive glass (46S6) after their association by adsorption phenomenon. To more understand the interaction processes of RIS with the 46S6 surface we have used complementary physicochemical techniques such as Infrared (FTIR), RAMAN and nuclear magnetic resonance (NMR) spectroscopy. The obtained results suggest that risedronate adsorption corresponds to an ion substitution reaction with silicon ions occurring at the bioactive glass surface. Thus, a pure bioactive glass was synthesized and fully characterized comparing the solids after adsorption (46S6-XRIS obtained after the interaction of 46S6 and X% risedronate). Therefore, based on the spectroscopic results FTIR, RMAN and MAS-NMR, it can be concluded that strong interactions have been established between RIS ions and 46S6 surface. In fact, FTIR and RAMAN spectroscopy illustrate the fixation of risedronate on the bioactive glass surface by the appearance of several bands characterizing risedrontre. The 31P MAS-NMR of the composite 46S6-XRIS show the presence of two species at a chemical shift of 15 and 19 ppm demonstrating thus the fixation of the RIS on 46S6 surface.

Keywords: Adsorption; bioactive glass; Bisphosphonate; Risedronate; Spectroscopy

Domains: Chemical Sciences

Siwar Mosbahi, Hassane Oudadesse, Bertand Lefeuvre, Allal Barroug, Hafed Elfeki, et al.. Risedronate adsorption on bioactive glass surface for applications as bone biomaterial. Applied Surface Science, 2016, 367, pp.205-213. ⟨10.1016/j.apsusc.2016.01.184⟩. ⟨hal-01263041⟩