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Statin use is safe and does not impact prognosis in patient with de novo follicular lymphoma treated with immunochemotherapy: An exploratory analysis of the PRIMA cohort study

Abstract : An adverse prognostic impact of statin use in lymphoma was first suspected from in vitro data showing an impairment of anti-CD20 antibody binding. However, further clinical studies suggested an improved outcome associated with their use in hematological malignancies. In particular, a survival benefit was reported for patients with follicular lymphoma on statins. Our objective was to assess the outcome of follicular lymphoma patients treated in the PRIMA study with immunochemotherapy according to the use of statins. Among the 1217 patients enrolled in the PRIMA study, 1135 were included in the present study. Concomitant treatments at registration were available for all patients. Among those 1135 patients, 119 were on statins (10.4%) at diagnosis. Adverse events frequencies, event-free survival (EFS), time to next lymphoma treatment (TTNLT), time to next chemotherapy (TTNCT) and overall survival (OS) were evaluated according to the use of statins. The rates of overall and specific cardiovascular adverse events between the 2 groups of patients were comparable both during induction and maintenance. Outcome in terms of response rates or EFS, TTNLT, TTNCT and OS were similar regardless of the use of statins (P=.57, P=.85, P=.30 and P=.43 respectively) in univariate analysis and after further adjustments for potential confounding factors in multivariate analysis. In conclusion, statin use does not impact the prognosis of patients with follicular lymphoma treated with immunochemotherapy. This article is protected by copyright. All rights reserved
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Submitted on : Tuesday, May 10, 2016 - 3:02:02 PM
Last modification on : Wednesday, May 13, 2020 - 11:44:02 AM
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Emmanuel Bachy, Jane A. Estell, Eric Neste, Reda Bouabdallah, Joan Bargay, et al.. Statin use is safe and does not impact prognosis in patient with de novo follicular lymphoma treated with immunochemotherapy: An exploratory analysis of the PRIMA cohort study. American Journal of Hematology, Wiley, 2016, 91 (4), pp.410-415. ⟨10.1002/ajh.24305⟩. ⟨hal-01263105⟩

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