. Providing-hepg2, P. /. Hep3b, and . Prf, HLE, and HLF purchased from ATCC and HuH7 purchased from JCRB (Japanese Collection of Research Bioresources Cell Bank); Prof Institute of Pathology, Cologne, Germany, for FLC-4 and HuH6 cells; and Prof. Scott Friedman, Mount Sinai Hospital, Icahn Medical Institute New York, USA, for LX-2. The authors thankLaboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute) for kindly providing c-myc and TGF? transgenic mice, Thanks to Alexandra Müller (Medical Faculty Mannheim/UMM) and Igor Liebermann (IKP Stuttgart) for technical help. We also thank the interpreter Mrs. S. Namingha for proofreading the manuscript

T. Abbreviations, . Growth-factor, and I. Tgf-?r-i, Transforming growth factor receptor type I, II and III, CM -collagen monolayer, CLD -chronic liver disease, Col1a1 ? Collagen 1a1, CS -collagen sandwich, ELISA ? enzyme?linked immunosorbent assay, HCC -hepatocellular carcinoma, HSC -hepatic stellate cell, CCL 4 ? carbontetrachloride, BDL -bile duct ligation, DEN -diethylnitrosamine, ICC -intrahepatic cholangiocarcinoma, DMEM -Dulbecco?s Modified Eagle Medium, KO -knock out, MDR2 ? multi drug resistance protein 2, phosphatidyl flippase, qPCR -quantitative realtime polymerase chain reaction, SYBR -N?,N?- dimethyl-N-[4-[(E)-(3-methyl-1,3-benzothiazol-2-ylidene) methyl]-1-phenylquinolin-1-ium-2-yl]-N-propylpropane- 1,3-diamine, LX-2 ? human hepatic stellate cell line Lieming Xu-2 HuH7 -human hepatocellular carcinoma cell lines, HuH6 ? human hepatoblastoma cell line

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