Altered synchrony and loss of consciousness during frontal lobe seizures

Francesca Bonini (1, 2) , Isabelle Lambert (2) , Fabrice Wendling (3) , Aileen Mcgonigal (1, 2) , Fabrice Bartolomei (1, 2)

1 INS - Institut de Neurosciences des Systèmes
2 Service de Neurophysiologie Clinique
3 LTSI - Laboratoire Traitement du Signal et de l'Image

Objective Loss of consciousness (LOC) in frontal lobe epilepsy (FLE) has been rarely specifically studied until now. In this study we evaluated the LOC in a population of patients with FLE and studied the relationship between changes in synchrony and degree of LOC. Methods 24 patients undergoing stereoelectroencephalography (SEEG) during pre-surgical evaluation of FLE were studied. The LOC intensity was scored using the Consciousness Seizure Scale (CSS). For each studied seizure (n = 52), interdependencies between signals recorded from 5 brain regions were estimated as a function of time by using non-linear regression analysis (h2 coefficient). Results Seizures were divided into 3 groups according to the CSS scale: group A (no LOC) with a score ⩽2, group B (intermediate or partial LOC) with a score ranging from 3 to 5, and group C (maximal LOC) with a score ⩾6. The majority of seizures in FLE patients disclosed significant LOC, particularly for patients with prefrontal lobe seizures. Mean correlation values were significantly different between groups A and C (p < 0.001), the maximal values of synchrony being observed in group C. Differences were significant for interaction affecting the external prefrontal cortex (p = 0.004) (p = 0.01) and the parietal cortex. In addition, a significant correlation was found between CSS scores and correlations values (h2) of the prefrontal and the parietal region but not with the premotor cortex. Conclusions This study indicates that in FLE, prefrontal seizures frequently alter consciousness. As in other focal seizures, LOC appears to be related to changes in synchrony in prefrontal and parietal associative cortices.

Mots clés: Consciousness; Frontal cortex; Synchrony; Focal epilepsy

Domaines: Sciences du Vivant [q-bio]

Francesca Bonini, Isabelle Lambert, Fabrice Wendling, Aileen Mcgonigal, Fabrice Bartolomei. Altered synchrony and loss of consciousness during frontal lobe seizures. Clinical Neurophysiology, 2016, 127 (2), pp.1170-1175. ⟨10.1016/j.clinph.2015.04.050⟩. ⟨hal-01272543⟩