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Graphical Abstract Biocatalyzed synthesis of difuranosides and their ability to trigger production of TNF-D D Biocatalyzed synthesis of difuranosides and their ability to trigger production of TNF-D D

Abstract : Transglycosylation reactions biocatalyzed by the native arabinofuranosidase Araf51 and using D-galactosyl, D-fucosyl and 6-deoxy-6-fluoro-D-galactosyl derivatives as donors and acceptors provided di-to pentahexofuranosides. The immunostimulatory potency of these compounds, and more especially their ability to induce production of TNF-α, was evaluated on the murine macrophage cell line, Raw 264.7. The results obtained showed concentration-dependent and most importantly, structure-dependent responses. Interestingly, oligoarabinofuranosides belonging to the oligopentafuranoside family displayed concentration-, chain length and aglycon-dependent bioactivities irrespective of their fine chemical variations. Thus, neo-oligofuranosides in D-Galf series, as well as their D-Fucf and 6-fluorinated counterparts are indeed potential sources of immunostimulating agents.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01272616
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Submitted on : Thursday, February 11, 2016 - 10:33:55 AM
Last modification on : Thursday, March 5, 2020 - 2:06:42 PM
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Ilona Chlubnová, Blanka Králová, Hana Dvořáková, Vojtěch Spiwok, Dominik Filipp, et al.. Graphical Abstract Biocatalyzed synthesis of difuranosides and their ability to trigger production of TNF-D D Biocatalyzed synthesis of difuranosides and their ability to trigger production of TNF-D D. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26 (6), pp.1550-1553. ⟨10.1016/j.bmcl.2016.02.018⟩. ⟨hal-01272616⟩

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