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Origine développementale de la santé et des maladies (DOHaD), environnement et épigénétique [DOHaD: epidemiological researches]

Cyrille Delpierre 1 Johanna Lepeule 2 Sylvaine Cordier 3 Rémy Slama 4, 2 Barbara Heude 5 Marie-Aline Charles 5
1 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
2 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
3 Irset - Institut de recherche en santé, environnement et travail
4 Equipe avenir "Environmental Epidemiology Applied to Fecundity and Reproduction"
5 CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
Abstract : Epidemiological researches in the field of DOHaD are in favor of a role of early environment, including chemical (pesticides), physical (air pollution), nutritional or psychosocial environment, on child and adult health. Disentangling the different factors of environment that may affect health, especially over time, and identifying critical periods of exposure remains a major challenge. The biological mechanisms involved remain elusive in human beings. Nevertheless, it seems that whatever the nature of the exposure, epigenetic mechanisms are currently discussed to explain how the environment may alter biological systems over time.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274219
Contributor : Laurent Jonchère <>
Submitted on : Monday, February 15, 2016 - 4:03:54 PM
Last modification on : Friday, May 29, 2020 - 3:52:05 PM

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UNIV-RENNES1 | U823 | IRSET | BIOSIT | UGA | UR1-UFR-SVE | USPC | IRSET-9 | UNIV-ANGERS | UNIV-PARIS5 | INRA | UNIV-RENNES | UNIV-PARIS7 | UNIV-TLSE3 | INRAE | UNIV-PARIS | UP-SANTE

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Cyrille Delpierre, Johanna Lepeule, Sylvaine Cordier, Rémy Slama, Barbara Heude, et al.. Origine développementale de la santé et des maladies (DOHaD), environnement et épigénétique [DOHaD: epidemiological researches]. médecine/sciences, EDP Sciences, 2016, 32 (1), pp.21--26. ⟨10.1051/medsci/20163201005⟩. ⟨hal-01274219⟩

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