Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Pierre-Emmanuel Noly (1) , Julien Guihaire (2, 1) , Matthieu Coblence (1) , Peter Dorfmüller (3, 4, 1) , Elie Fadel (1) , Olaf Mercier (1)

1 CCML - Centre Chirurgical Marie Lannelongue
2 Service de chirurgie thoracique cardiaque et vasculaire [Rennes] = Thoracic and Cardiovascular Surgery [Rennes]
3 DHU TORINO - Service de Pneumologie et Réanimation Respiratoire
4 UP11 - Université Paris-Sud - Paris 11

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure

Domains: Life Sciences [q-bio]

Pierre-Emmanuel Noly, Julien Guihaire, Matthieu Coblence, Peter Dorfmüller, Elie Fadel, et al.. Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet. Journal of visualized experiments : JoVE, 2015, 105, ⟨10.3791/53133⟩. ⟨hal-01275478⟩