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Spindle Micro-Fluctuations of Length Reveal its Dynamics Over Cell Division

Abstract : 3074-Pos. The mitotic spindle ensures correct segregation of sister chromatids and correct partitioning in daughter cells. It comprises dynamical microtubules (alternating polymerizing and depolymerizing), a variety of molecular motors and their regulators. Although spindle structure is well known, the link to its functions remains elusive, calling for including the dynamics of its components and their interactions. This question was mostly investigated by in silico or in vitro approaches. But a detailed characterizing of spindle mechanics, in physiological conditions, is missing
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01275520
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, February 17, 2016 - 3:48:00 PM
Last modification on : Wednesday, October 14, 2020 - 4:03:42 AM

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Benjamin Mercat, Xavier Pinson, Jonathan Fouchard, Hadrien Mary, Sylvain Pastezeur, et al.. Spindle Micro-Fluctuations of Length Reveal its Dynamics Over Cell Division. Biophysical Journal, Biophysical Society, 2016, 110 (3), pp.622a. ⟨10.1016/j.bpj.2015.11.3338⟩. ⟨hal-01275520⟩

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