Efficacy of Azacitidine in Autoimmune and Inflammatory Disorders associated with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia

Jean-Baptiste Fraison (1) , Arsène Mekinian (2) , Eric Grignano (3) , Jean-Emmanuel Kahn (4) , Jean-Benoit Arlet (5) , Olivier Decaux (6, 7) , Guillaume Denis (8) , Anne-Laure Buchdahl (9) , Mohamed Omouri (10) , Gwenola Maigne (11) , Achille Aouba (11) , Nathalie Leon (11) , Sabine Berthier (12) , Eric Liozon (13) , Sophie Park (14) , Claude Gardin (15) , Olivier Lortholary (16) , Julien Rossignol (3) , Pierre Fenaux (17) , Olivier Fain (2) , Thorsten Braun (15)

1 Hôpital Jean Verdier [AP-HP]
2 DHU - I2B - Departement Hospitalo- Universitaire - Inflammation, Immunopathologie, Biothérapie [Paris]
3 Hématologie
4 Hôpital Foch [Suresnes]
5 HEGP - Hôpital Européen Georges Pompidou [APHP]
6 IGDR - Institut de Génétique et Développement de Rennes
7 Hôpital Pontchaillou
8 CH de Rochefort
9 Centre Hospitalier [Douai, Nord]
10 Centre hospitalier Maurice Camuset [Romilly]
11 CHU Caen
12 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
13 CHU Limoges
14 CHU Grenoble
15 Hôpital Avicenne [AP-HP]
16 CHU Necker - Enfants Malades [AP-HP]
17 Hôpital Saint-Louis

This retrospective study describes efficacy of Azacitidine on autoimmune disorders (AID) associated with MDS/CMML in 22 patients. Response of AID to Azacitidine was observed in 19 patients (86%). Reduction or discontinuation of steroids and/or immunosuppressive therapy (IST) was possible in 16 cases (73%). Hematologic response was seen in 55% of the patients. MDS/CMML and AID evolution was concordant in 13 cases (59%): both favorable (n = 11), both unfavorable (n = 2), but AID improved while MDS/CMML worsened (n = 8) and vice versa (n = 1). Azacitidine frequently seems effective in controlling steroid-dependent AID associated with MDS/CMML, but prospective studies are necessary to confirm those findings

Keywords: myelodysplastic syndromes; auto immune disorders; Azacitidine

Domains: Life Sciences [q-bio]; Cancer

Jean-Baptiste Fraison, Arsène Mekinian, Eric Grignano, Jean-Emmanuel Kahn, Jean-Benoit Arlet, et al.. Efficacy of Azacitidine in Autoimmune and Inflammatory Disorders associated with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia. Leukemia Research, 2016, 43, pp.13-17. ⟨10.1016/j.leukres.2016.02.005⟩. ⟨hal-01278608⟩