Skip to Main content Skip to Navigation
Journal articles

Efficacy of Azacitidine in Autoimmune and Inflammatory Disorders associated with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia

Abstract : This retrospective study describes efficacy of Azacitidine on autoimmune disorders (AID) associated with MDS/CMML in 22 patients. Response of AID to Azacitidine was observed in 19 patients (86%). Reduction or discontinuation of steroids and/or immunosuppressive therapy (IST) was possible in 16 cases (73%). Hematologic response was seen in 55% of the patients. MDS/CMML and AID evolution was concordant in 13 cases (59%): both favorable (n = 11), both unfavorable (n = 2), but AID improved while MDS/CMML worsened (n = 8) and vice versa (n = 1). Azacitidine frequently seems effective in controlling steroid-dependent AID associated with MDS/CMML, but prospective studies are necessary to confirm those findings
Document type :
Journal articles
Complete list of metadatas

Cited literature [16 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01278608
Contributor : Nelly Brenner <>
Submitted on : Tuesday, June 7, 2016 - 5:04:31 PM
Last modification on : Sunday, October 25, 2020 - 7:08:10 AM

File

Efficacy of Azacitidine in Aut...
Files produced by the author(s)

Identifiers

Citation

Jean-Baptiste Fraison, Arsène Mekinian, Eric Grignano, Jean-Emmanuel Kahn, Jean-Benoit Arlet, et al.. Efficacy of Azacitidine in Autoimmune and Inflammatory Disorders associated with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia. Leukemia Research, Elsevier, 2016, 43, pp.13-17. ⟨10.1016/j.leukres.2016.02.005⟩. ⟨hal-01278608⟩

Share

Metrics

Record views

974

Files downloads

1872