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Journal articles
Efficacy of Azacitidine in Autoimmune and Inflammatory Disorders associated with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia
Jean-Baptiste Fraison
1, *
Arsène Mekinian
2
Eric Grignano
3
Jean-Emmanuel Kahn
4
Jean-Benoit Arlet
5
Olivier Decaux
6, 7
Guillaume Denis
8
Anne-Laure Buchdahl
9
Mohamed Omouri
10
Gwenola Maigne
11
Achille Aouba
11
Nathalie Leon
11
Sabine Berthier
12
Eric Liozon
13
Sophie Park
14
Claude Gardin
15
Olivier Lortholary
16
Julien Rossignol
3
Pierre Fenaux
17
Olivier Fain
2
Thorsten Braun
18
Jean-Baptiste Fraison 1
Correspondent author
Arsène Mekinian 2
Author
Eric Grignano 3
Author
Jean-Emmanuel Kahn 4
Author
Jean-Benoit Arlet 5
Author
Olivier Decaux 6, 7
Author
Guillaume Denis 8
Author
Anne-Laure Buchdahl 9
Author
Olivier Lortholary 16
Author
Julien Rossignol 3
Author
Pierre Fenaux 17
Author
Olivier Fain 2
Author
Thorsten Braun 18
Author
1
Hôpital Jean Verdier [AP-HP] (France)
2
DHU - I2B - Departement Hospitalo- Universitaire - Inflammation, Immunopathologie, Biothérapie [Paris] (Bâtiment CERVI,
4ème étage,
Hôpital de la Pitié-Salpêtrière,
83 Bld. de l'Hôpital,
75013 Paris - France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
3
Hématologie (France)
- Département de médecine oncologique [Gustave Roussy] (Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- IGR - Institut Gustave Roussy (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
4
Hôpital Foch [Suresnes] (40 Rue Worth 92150 Suresnes - France)
5
HEGP - Hôpital Européen Georges Pompidou [APHP] (20, rue Leblanc, 75015 Paris - France)
6
IGDR - Institut de Génétique et Développement de Rennes (Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex - France)
- UR1 - Université de Rennes 1 (2 rue du Thabor - CS 46510 - 35065 Rennes cedex - France)
- UNIV-RENNES - Université de Rennes (France)
- CNRS - Centre National de la Recherche Scientifique : UMR6290 (France)
- Biosit : Biologie - Santé - Innovation Technologique - Structure Fédérative de Recherche en Biologie et Santé de Rennes (Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex - France)
7
Hôpital Pontchaillou (France)
8
CH de Rochefort (Centre hospitalier de Rochefort, 1 Avenue de Béligon, 17301 Rochefort - France)
9
Centre Hospitalier [Douai, Nord] (Centre Hospitalier de Douai, Route de Cambrai - BP10740 - 59507 Douai cedex - France)
10
Centre hospitalier Maurice Camuset [Romilly] (Centre Hospitalier de Romilly, rue Paul Vaillant Couturier 10105 Romilly-sur-Seine - France)
11
CHU Caen (Avenue de la Côte de Nacre 14000 Caen - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- TCBN - Tumorothèque de Caen Basse-Normandie (3 avenue du Général Harris 14076 Caen cedex 5 - France)
12
CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon - France)
13
CHU Limoges (Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES - France)
14
CHU Grenoble (France)
15
Hôpital Avicenne [AP-HP] (France)
16
CHU Necker - Enfants Malades [AP-HP] (149 Rue de Sèvres 75015 Paris - France)
17
Hôpital Saint-Louis (1, avenue Claude-Vellefaux 75475 PARIS Cedex 10 - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- UPD7 - Université Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
18
Hôpital avicenne (125, rue de Stalingrad 93000 Bobigny - France)
Abstract : This retrospective study describes efficacy of Azacitidine on autoimmune disorders (AID) associated with MDS/CMML in 22 patients. Response of AID to Azacitidine was observed in 19 patients (86%). Reduction or discontinuation of steroids and/or immunosuppressive therapy (IST) was possible in 16 cases (73%). Hematologic response was seen in 55% of the patients. MDS/CMML and AID evolution was concordant in 13 cases (59%): both favorable (n = 11), both unfavorable (n = 2), but AID improved while MDS/CMML worsened (n = 8) and vice versa (n = 1). Azacitidine frequently seems effective in controlling steroid-dependent AID associated with MDS/CMML, but prospective studies are necessary to confirm those findings
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Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01278608
Contributor : Nelly Brenner <>
Submitted on : Tuesday, June 7, 2016 - 5:04:31 PM
Last modification on : Thursday, December 10, 2020 - 3:43:28 AM
Contributor : Nelly Brenner <>
Submitted on : Tuesday, June 7, 2016 - 5:04:31 PM
Last modification on : Thursday, December 10, 2020 - 3:43:28 AM
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Identifiers
- HAL Id : hal-01278608, version 1
- DOI : 10.1016/j.leukres.2016.02.005
- PUBMED : 26922775
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CNRS | UPMC | UNIV-RENNES1 | FNCLCC | UNIV-PARIS13 | BIOSIT | IGR | USPC | UNIV-RENNES | SORBONNE-UNIVERSITE | UNIV-PARIS7 | SU-MEDECINE | COMUE-NORMANDIE | UNIV-PARIS | POLITIQUES-PUBLIQUES | SU-TI
Citation
Jean-Baptiste Fraison, Arsène Mekinian, Eric Grignano, Jean-Emmanuel Kahn, Jean-Benoit Arlet, et al.. Efficacy of Azacitidine in Autoimmune and Inflammatory Disorders associated with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia. Leukemia Research, Elsevier, 2016, 43, pp.13-17. ⟨10.1016/j.leukres.2016.02.005⟩. ⟨hal-01278608⟩
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