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Journal Articles Stem Cells International Year : 2016

Prospect of Stem Cells in Bone Tissue Engineering: A Review


Mesenchymal stem cells (MSCs) have been the subject of many studies in recent years, ranging from basic science that looks into MSCs properties to studies that aim for developing bioengineered tissues and organs. Adult bone marrow-derived mesenchymal stem cells (BM-MSCs) have been the focus of most studies due to the inherent potential of these cells to differentiate into various cell types. Although, the discovery of induced pluripotent stem cells (iPSCs) represents a paradigm shift in our understanding of cellular differentiation. These cells are another attractive stem cell source because of their ability to be reprogramed, allowing the generation of multiple cell types from a single cell. This paper briefly covers various types of stem cell sources that have been used for tissue engineering applications, with a focus on bone regeneration. Then, an overview of some recent studies making use of MSC-seeded 3D scaffold systems for bone tissue engineering has been presented. The emphasis has been placed on the reported scaffold properties that tend to improve MSCs adhesion, proliferation, and osteogenic differentiation outcomes

Dates and versions

hal-01279119 , version 1 (25-02-2016)



Azizeh-Mitra Yousefi, Paul F. James, Rosa Akbarzadeh, Aswati Subramanian, Conor Flavin, et al.. Prospect of Stem Cells in Bone Tissue Engineering: A Review. Stem Cells International, 2016, 2016, pp.6180487. ⟨10.1155/2016/6180487⟩. ⟨hal-01279119⟩
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