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Apical Vs. Non-apical Lead: Is ICD Lead Position ImportantX for Successful Defibrillation?

Abstract : INTRODUCTION: We aim to compare the acute and long-term success of defibrillation between non-apical and apical ICD lead position. METHODS AND RESULTS: The position of the ventricular lead was recorded by the implanting physician for 2475 of 2500 subjects in the Shockless IMPLant Evaluation (SIMPLE) trial, and subjects were grouped accordingly as non-apical or apical. The success of intra-operative defibrillation testing and of subsequent clinical shocks were compared. Propensity scoring was used to adjust for the impact of differences in baseline variables between these groups. There were 541 leads that were implanted at a non-apical position (21.9%). Patients implanted with a non-apical lead had a higher rate of secondary prevention indication. Non-apical location resulted in lower mean R-wave amplitude (14.0 vs. 15.2, p\textless 0.001), lower mean pacing impedance (662 Ohms vs. 728 Ohms, p\textless 0.001), and higher mean pacing threshold (0.70V vs. 0.66V, p = 0.01). Single-coil leads, and cardiac resynchronization devices were used more often in non-apical implants. The success of intra-operative defibrillation was similar between propensity score matched groups (89%). Over a mean follow-up of 3 years, there were no significant differences in the yearly rates of appropriate shock (5.5% vs. 5.4%, p = 0.98), failed appropriate first shock (0.9% vs. 1.0%, p = 0.66) or the composite of failed shock or arrhythmic death (2.8% vs. 2.3% p = 0.35) according to lead location. CONCLUSION: We did not detect any reduction in the ICD efficacy at the time of implant or during follow-up in patients receiving a non-apical RV lead. This article is protected by copyright. All rights reserved
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Submitted on : Thursday, March 3, 2016 - 3:40:51 PM
Last modification on : Friday, January 15, 2021 - 3:34:00 AM

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Guy Amit, Jia Wang, Stuart J. Connolly, Michael Glikson, Stephan Hohnloser, et al.. Apical Vs. Non-apical Lead: Is ICD Lead Position ImportantX for Successful Defibrillation?. Journal of Cardiovascular Electrophysiology, Wiley, 2016, 27 (5), pp.581-586. ⟨10.1111/jce.12952⟩. ⟨hal-01282345⟩



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