Vaccination coverage of children with inflammatory bowel disease after an awareness campaign on the risk of infection

Aude Fleurier (1) , Cecile Pelatan (2) , Stephanie Willot (3) , Jean-Louis Ginies (4) , Estelle Breton (5) , Laure Bridoux (1) , Jean-Francois Segura (6) , Emilie Chaillou (4) , Agathe Jobert (7) , Estelle Darviot (4) , Benoit Cagnard (8) , Nadege Delaperriere (6) , Isabelle Grimal (9) , Emilie Carré (1) , Anne-Claire Wagner (7) , Emmanuelle Sylvestre (1) , Alain Dabadie (10)

1 CHU Pontchaillou [Rennes]
2 Centre Hospitalier Le Mans (CH Le Mans)
3 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
4 CHU Angers - Centre Hospitalier Universitaire d'Angers
5 Pôle Médico-Chirurgical de Pédiatrie et de Génétique Clinique
6 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
7 Centre hospitalier de Saint-Nazaire
8 CH Vannes
9 CH Cholet
10 Service de Pédiatrie

BACKGROUND: Children with inflammatory bowel disease are at risk of vaccine-preventable diseases mostly due to immunosuppressive drugs. AIM: To evaluate coverage after an awareness campaign informing patients, their parents and general practitioner about the vaccination schedule. METHODS: Vaccination coverage was firstly evaluated and followed by an awareness campaign on the risk of infection via postal mail. The trial is a case-control study on the same patients before and after the awareness campaign. Overall, 92 children were included. A questionnaire was then completed during a routine appointment to collect data including age at diagnosis, age at data collection, treatment history, and vaccination status. RESULTS: Vaccination rates significantly increased for vaccines against diphtheria-tetanus-poliomyelitis (92% vs. 100%), Haemophilus influenzae (88% vs. 98%), hepatitis B (52% vs. 71%), pneumococcus (36% vs. 57%), and meningococcus C (17% vs. 41%) (p\textless0.05). Children who were older at diagnosis were 1.26 times more likely to be up-to-date with a minimum vaccination schedule (diphtheria-tetanus-poliomyelitis, pertussis, H. influenzae, measles-mumps-rubella, tuberculosis) (p=0.002). CONCLUSION: Informing inflammatory bowel disease patients, their parents and general practitioner about the vaccination schedule via postal mail is easy, inexpensive, reproducible, and increases vaccination coverage. This method reinforces information on the risk of infection during routine visits

Keywords: Adolescent; Awareness-raising; Case-Control Studies; Child; Preschool; Children; Female; Follow-Up Studies; Health Promotion; Humans; IBD; Immunization Schedule; Inflammatory Bowel Diseases; Male; Opportunistic Infections; Outcome Assessment (Health Care); Patient Education as Topic; Prospective Studies; Vaccination; Young Adult

Domains: Life Sciences [q-bio]

Aude Fleurier, Cecile Pelatan, Stephanie Willot, Jean-Louis Ginies, Estelle Breton, et al.. Vaccination coverage of children with inflammatory bowel disease after an awareness campaign on the risk of infection. Digestive and Liver Disease, 2015, 47 (6), pp.460--464. ⟨10.1016/j.dld.2015.02.009⟩. ⟨hal-01282354⟩