A new direct synthesis of α-methylene- and α-alkylidene-β-lactams

Marwa Hussein (1, 2) , Assaad Nasr El Dine (1, 2) , Fares Fares (1) , Vincent Dorcet (2) , Ali Hachem (1) , René Grée (2)

1 LU - Lebanese University [Beirut]
2 ISCR - Institut des Sciences Chimiques de Rennes

The Kinugasa reaction applied to alkynes bearing a nucleofuge in propargylic position affords directly, and in fair yields, α-methylene- or α-alkylidene- β-lactams

Keywords: Propargyl derivatives; Nitrones; Kinugasa reaction; beta-Lactams; Alkynes

Domains: Chemical Sciences; Organic chemistry; Life Sciences [q-bio]; Pharmaceutical sciences

Marwa Hussein, Assaad Nasr El Dine, Fares Fares, Vincent Dorcet, Ali Hachem, et al.. A new direct synthesis of α-methylene- and α-alkylidene-β-lactams. Tetrahedron Letters, 2016, 57 (18), pp.1990-1993. ⟨10.1016/j.tetlet.2016.03.083⟩. ⟨hal-01295513⟩