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Apomorphine en perfusion sous-cutanée continue dans la maladie de Parkinson : le point de vue pharmacologique

Abstract : Subcutaneous infusion with apomorphine is one of the treatments available for Parkinson's disease. Even if increasing evidence of its efficacy on both motor and non-motor symptoms is found in the literature, it is still underused. This article reviews pharmacological and pharmacokinetic properties of apomorphine and its impact on clinical decision making. Despite their complexity, those properties are a key to understanding the effect of the drug and its variability of efficacy and dosage amongst patients.
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Submitted on : Friday, July 22, 2016 - 11:49:14 AM
Last modification on : Friday, September 6, 2019 - 10:18:02 AM
Long-term archiving on: : Sunday, October 23, 2016 - 12:20:54 PM

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Manon Auffret, Sophie Drapier, Marc Verin, Paul Sauleau. Apomorphine en perfusion sous-cutanée continue dans la maladie de Parkinson : le point de vue pharmacologique. Pratique Neurologique - FMC, 2016, 7 (1), pp.25--32. ⟨10.1016/j.praneu.2016.01.006⟩. ⟨hal-01295662⟩

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