G. Minot, Megakaryocytes in the peripheral circulation, J Exp Med, vol.36, issue.1, 1922.

J. Bennett, D. Catovsky, M. Daniel, G. Flandrin, D. Galton et al., Proposals for the classification of the myelodysplastic syndromes, British Journal of Haematology, vol.92, issue.2, pp.189-199, 1982.
DOI : 10.1016/0145-2126(79)90006-7

J. Bennett, D. Catovsky, M. Daniel, G. Flandrin, D. Galton et al., Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7), Annals of Internal Medicine, vol.103, issue.3, pp.460-462, 1985.
DOI : 10.7326/0003-4819-103-3-460

R. Brunning, A. Orazi, U. Germing, L. Beau, M. Porwit et al., Myelodysplastic syndromes/neoplasms, overview World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Thiele J and Vardiman JW, pp.88-93, 2008.

D. Arber, R. Brunning, A. Orazi, B. Bain, A. Porwit et al., Acute myeloid leukaemia with myelodysplasia-related changes World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Thiele J and Vardiman JW, pp.124-126, 2008.

D. Arber and R. Hasserjian, Reclassifying myelodysplastic syndromes: what's where in the new WHO and why, Hematology, vol.2015, issue.1, pp.294-298, 2015.
DOI : 10.1182/asheducation-2015.1.294

K. Kuriyama, M. Tomonaga, T. Matsuo, I. Ginnai, and M. Ichimaru, Diagnostic significance of detecting pseudo-Pelger-Huet anomalies and micro-megakaryocytes in myelodysplastic syndrome, British Journal of Haematology, vol.59, issue.4, pp.665-669, 1986.
DOI : 10.1016/0145-2126(79)90007-9

B. Bain, The bone marrow aspirate of healthy subjects, British Journal of Haematology, vol.94, issue.1, pp.206-209, 1996.
DOI : 10.1046/j.1365-2141.1996.d01-1786.x

J. E. Maldonado, Dysplastic platelets and circulating megakaryocytes in chronic myeloproliferative diseases. II ultrastructure of circulating megakaryocytes, Blood, vol.43, pp.811-820, 1974.

E. Duchayne, O. Fenneteau, M. Pages, D. Sainty, C. Arnoulet et al., Acute Megakaryoblastic Leukaemia: A National Clinical and Biological Study of 53 Adult and Childhood Cases by the Groupe Fran??ais d'H??matologie Cellulaire (GFHC), Leukemia & Lymphoma, vol.44, issue.1, pp.49-58, 2003.
DOI : 10.1080/1042819021000040279

C. Litz, S. Davies, R. Brunning, B. Kurk, J. Parkin et al., Acute leukemia and transient myeloproliferative disorder associated with Down syndrome: morphologic immunophenotypic and cytogenetic manifestations, Leukemia, vol.9, pp.1432-1439, 1995.

S. Franzén, G. Strenger, and J. Zajicek, Microplanimetric Studies on Megakaryocytes in Chronic Granulocytic Leukaemia and Polycythaemia Vera, Acta Haematologica, vol.26, issue.3, pp.182-193, 1961.
DOI : 10.1159/000206652

A. Matsuda, I. Jinnai, Y. Miyazaki, and T. , Proposals for a Grading System for Diagnostic Accuracy of Myelodysplastic Syndromes, Clinical Leukemia, vol.2, issue.2, pp.102-106, 2008.
DOI : 10.3816/CLK.2008.n.012

D. Majority and . Dysplasia, 1' only) * Majority for Dysplasia ('1'+ '2')* Independently Dysplasia ('1' only) Independently Dysplasia

*. A1, A. , and A. , are autoimmune thrombocytopenia; C1 and C2 are acute lymphoblastic leukemia in remission; ML, is a healthy volunteer. ? '1' = dysplastic