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0019: High-degree atrioventricular block complicating ST-segment elevation myocardial infarction in the contemporary era: data from the ORBI prospective French regional registry

Vincent Auffret 1, 2, 3 Aurélie Loirat 2, 1 Guillaume Leurent 2, 3, 1 Raphael Martins 2, 1 Emmanuelle Filippi 4 Isabelle Coudert Jean-Philippe Hacot Martine Gilard 5 Philippe Castellant 5 Antoine Rialan 6 Régis Delaunay 6 Gilles Rouault 7 Philippe Druelles 8 Bertrand Boulanger 8 Josiane Treuil 8 Bertrand Avez Marc Bedossa 2, 1 Dominique Boulmier 2, 1 Marielle Le Guellec 9 Jean-Claude Daubert 1, 2 Hervé Le Breton 2, 9
1 Service de cardiologie et maladies vasculaires
2 LTSI - Laboratoire Traitement du Signal et de l'Image
3 CIC-IT Rennes
4 Service de cardiologie [Vannes]
5 ORPHY (EA 4324) - Optimisation des régulations physiologiques
6 Service de cardiologie [Saint Malo]
7 Service de cardiologie [Quimper]
8 Service de cardiologie [Rennes]
9 CHU Pontchaillou [Rennes]
Abstract : Background High-degree atrioventricular block (HAVB) is a common complication of ST-segment elevation myocardial infarction (STEMI). HAVB in STEMI is historically considered as a marker of worse outcome but overall data about HAVB in the contemporary era of mechanical reperfusion and potent antiplatelet therapies are scarce. Aim We aimed at analyzing incidence, clinical correlates and impact on inhospital outcomes of HAVB in a large prospective registry (ORBI) of modern management of STEMI with a special focus on potential differences between patients with HAVB on admission and those who developed HAVB during hospitalization. Methods All patients enrolled in ORBI between June 2006 and December 2013 were included in the present analysis and were divided into 3 groups: patients without HAVB at any time, patients with HAVB on admission and those who developed HAVB during hospitalization. Results 6662 patients (age: 62.0 [52.0-74.0]; male: 76.3%) were included in the present analysis. HAVB was documented in 3.5% of patients, present on admission in 63.7% of patients and occurring during hospitalization in 36.3%. Patients with HAVB on admission or occurring during the first 24h of hospitalization had higher in-hospital mortality rates (18.1% and 28.6% respectively) than patients without (4.5%) or with HAVB occurring beyond the first 24h of hospitalization (8.0%). However by multivariable analysis, HAVB was not independently associated with in-hospital mortality. Conclusion Patients with HAVB had a higher mortality rate than patients without. However HAVB is not an independent predictor of in-hospital mortality. Abstract 0019 – Figure: Multivariable analysis
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302071
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, April 13, 2016 - 3:17:49 PM
Last modification on : Thursday, January 14, 2021 - 11:24:52 AM

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UNIV-RENNES1 | LTSI | UNIV-BREST | CIC | UR1-UFR-SVE | BIOSIT | UNIV-RENNES | ORPHY | IBSAM | POLITIQUES-PUBLIQUES

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Vincent Auffret, Aurélie Loirat, Guillaume Leurent, Raphael Martins, Emmanuelle Filippi, et al.. 0019: High-degree atrioventricular block complicating ST-segment elevation myocardial infarction in the contemporary era: data from the ORBI prospective French regional registry. Archives of Cardiovascular Diseases Supplements, Elsevier/French Society of Cardiology, 2016, 26es Journées européennes de la Société Française de cardiologie, 8 (1), pp.20--21. ⟨10.1016/S1878-6480(16)30062-3⟩. ⟨hal-01302071⟩

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