Synthesis of 3-substituted indolizidines from amino-ynones derivatives
Résumé
Two types of indolizidine derivatives can be synthesized from amino-ynones. In the presence of methanesulfonic acid, Meyer-Schuster rearrangement furnished vinylogues of indolizidin-3-ones whereas treatment with zinc chloride gave stable 3-alkynyl-1,5,6,7,8,8a-hexahydroindolizine-zinc complexes that were reduced to 3-alkynylindolizidines.
Domaines
Chimie organique
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Synthesis of 3-substituted indolizidines_accepted.pdf (179.09 Ko)
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