Improved method of S-alkylation of 2-mercaptobenzimidazole derivatives with trialkylphosphite

A. El-Kihel , S. Zouitina (1) , S. Guesmi (1) , M. Ahbala , P. Bauchat (2) , B. Biersack

1 LCCA - Laboratoire de Chimie de Coordination et Analytique
2 ISCR - Institut des Sciences Chimiques de Rennes

A new method of S-alkylation of 2-mercaptobenzimidazole derivatives has been developed by the condensation of these heterocycles with trialkylphosphite in the presence of phosphorus oxychloride giving the corresponding 2-S-alkylbenzimidazoles. The structure of the obtained products has been established by spectroscopic data.

Domaines: Chimie

A. El-Kihel, S. Zouitina, S. Guesmi, M. Ahbala, P. Bauchat, et al.. Improved method of S-alkylation of 2-mercaptobenzimidazole derivatives with trialkylphosphite. Chemistry - An Asian Journal, 2016, 28 (6), pp.1267--1269. ⟨10.14233/ajchem.2016.19647⟩. ⟨hal-01341573⟩