“Fibrous nests” in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome

Romain Désert (1) , Sihem Mebarki (1) , Mireille Desille (1) , Marie Sicard (1) , Elise Lavergne (1) , Stéphanie Renaud (1) , Damien Bergeat (1) , Laurent Sulpice (1) , Christine Perret (2) , Bruno Turlin (1) , Bruno Clément (1) , Orlando Musso (1)

1 Foie, métabolismes et cancer
2 IC UM3 (UMR 8104 / U1016) - Institut Cochin

Keywords: hepatocellular carcinoma; transit-amplifying liver progenitor cells; SFRP; extracellular matrix remodeling; tumor microenvironment; Wnt; LGR5; β-catenin; fibrogenesis; stem cells; CD44

Domains: Life Sciences [q-bio]; Cancer; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]; Life Sciences [q-bio]; Cellular Biology; Subcellular Processes [q-bio.SC]; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Life Sciences [q-bio]; Quantitative Methods [q-bio.QM]; Life Sciences [q-bio]; Biodiversity; Statistics [stat]; Life Sciences [q-bio]; Life Sciences [q-bio]; Human health and pathology; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Molecular biology

Romain Désert, Sihem Mebarki, Mireille Desille, Marie Sicard, Elise Lavergne, et al.. “Fibrous nests” in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome. International Journal of Biochemistry and Cell Biology, 2016, 81 (Part A), pp.195-207. ⟨10.1016/j.biocel.2016.08.017⟩. ⟨hal-01357500⟩