Biomarkers associated with checkpoint inhibitors

G. Manson (1) , J. Norwood (1) , A. Marabelle (2, 3) , H. Kohrt (4) , R. Houot (5)

1 CHU Pontchaillou [Rennes]
2 DITEP - Département d’Innovation Thérapeutique et essais précoces [Gustave Roussy]
3 UMR 1015 - Immunologie des tumeurs et immunothérapie
4 Stanford University
5 MiCa - Microenvironnement et cancer

Checkpoint inhibitors (CPI), namely anti-CTLA4 and anti-PD1/PD-L1 antibodies, demonstrated efficacy across multiple types of cancer. However, only subgroups of patients respond to these therapies. Additionally, CPI can induce severe immune-related adverse events (irAE). Biomarkers that predict efficacy and toxicity may help define the patients who may benefit the most from these costly and potentially toxic therapies. In this study, we review the main biomarkers that have been associated with the efficacy (pharmacodynamics and clinical benefit) and the toxicity (irAE) of CPIs in patients.

Keywords: suppressor-cells; clinical-response; expanded access program; regulatory t-cells; lymphocyte-associated antigen-4; advanced melanoma patients; metastatic melanoma; ctla-4 blockade; ipilimumab treatment; cancer-patients

Domains: Life Sciences [q-bio]; Cancer; Life Sciences [q-bio]; Immunology

G. Manson, J. Norwood, A. Marabelle, H. Kohrt, R. Houot. Biomarkers associated with checkpoint inhibitors. Annals of Oncology, 2016, 27 (7), pp.1199--1206. ⟨10.1093/annonc/mdw181⟩. ⟨hal-01359396⟩