Skip to Main content Skip to Navigation
Journal articles

Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects

Abstract : Paracetamol and NSAIDs, in particular acetylsalicylic acid (aspirin) and ibuprofen, are among the most used and environmentally released pharmaceutical drugs. The differences in international trends in the sale and consumption of mild analgesics reflect differences in marketing, governmental policies, habits, accessibility, disease patterns and the age distribution of each population. Biomonitoring indicates ubiquitous and high human exposure to paracetamol and to salicylic acid, which is the main metabolite of acetylsalicylic acid. Furthermore, evidence suggests that analgesics can have endocrine disruptive properties capable of altering animal and human reproductive function from fetal life to adulthood in both sexes. Medical and public awareness about these health concerns should be increased, particularly among pregnant women.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01359566
Contributor : Laurent Jonchère <>
Submitted on : Friday, September 2, 2016 - 4:18:20 PM
Last modification on : Thursday, June 4, 2020 - 4:06:08 PM

Identifiers

Citation

David M. Kristensen, Séverine Mazaud-Guittot, Pierre Gaudriault, Laurianne Lesné, Tania Serrano, et al.. Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects. Nature Reviews Endocrinology, Nature Publishing Group, 2016, 12 (7), pp.381--393. ⟨10.1038/nrendo.2016.55⟩. ⟨hal-01359566⟩

Share

Metrics

Record views

261