Multi-residue analytical method for human pharmaceuticals and synthetic hormones in river water and sewage effluents by solid-phase extraction and liquid chromatography???tandem mass spectrometry, Journal of Chromatography A, vol.1217, issue.44, pp.1217-6791, 2010. ,
DOI : 10.1016/j.chroma.2010.08.033
Toxicity of a Mixture of Dissimilarly Acting Substances to Natural Algal Communities:?? Predictive Power and Limitations of Independent Action and Concentration Addition, Environmental Science & Technology, vol.38, issue.23, pp.6363-6370, 2004. ,
DOI : 10.1021/es0497678
The expected effect of a combination of agents: the general solution, Journal of Theoretical Biology, vol.114, issue.3, pp.413-431, 1985. ,
DOI : 10.1016/S0022-5193(85)80176-4
Progestagens for human use, exposure and hazard assessment for the aquatic environment, Environmental Pollution, vol.157, issue.12, pp.3485-3494, 2009. ,
DOI : 10.1016/j.envpol.2009.06.012
URL : https://hal.archives-ouvertes.fr/hal-00455636
Screening Estrogenic Activities of Chemicals or Mixtures In Vivo Using Transgenic (cyp19a1b-GFP) Zebrafish Embryos, PLoS ONE, vol.21, issue.5, p.36069, 2012. ,
DOI : 10.1371/journal.pone.0036069.t002
URL : https://hal.archives-ouvertes.fr/hal-00877371
Selective Activation of Zebrafish Estrogen Receptor Subtypes by Chemicals by Using Stable Reporter Gene Assay Developed in a Zebrafish Liver Cell Line, Toxicological Sciences, vol.81, issue.2, pp.439-449, 2012. ,
DOI : 10.1093/toxsci/kfh180
URL : https://hal.archives-ouvertes.fr/hal-00750158
Identification of Synthetic Steroids in River Water Downstream from Pharmaceutical Manufacture Discharges Based on a Bioanalytical Approach and Passive Sampling, Environmental Science & Technology, vol.48, issue.7, pp.3649-3657, 2014. ,
DOI : 10.1021/es405313r
Effects of estradiol in adult neurogenesis and brain repair in zebrafish, Hormones and Behavior, vol.63, issue.2, pp.193-207, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00831715
Progestins as endocrine disrupters in aquatic ecosystems: Concentrations, effects and risk assessment, Environment International, vol.84, pp.115-130, 2015. ,
DOI : 10.1016/j.envint.2015.06.012
The intrinsic transcriptional estrogenic activity of a non-phenolic derivative of levonorgestrel is mediated via the estrogen receptor-??, The Journal of Steroid Biochemistry and Molecular Biology, vol.82, issue.4-5, pp.4-5, 2002. ,
DOI : 10.1016/S0960-0760(02)00192-9
A Unifying Concept for Assessing Toxicological Interactions: Changes in Slope, Toxicological Sciences, vol.88, issue.2, pp.287-297, 2005. ,
DOI : 10.1006/rtph.2002.1570
The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations, Aquatic Toxicology, vol.166, pp.1-9, 2015. ,
DOI : 10.1016/j.aquatox.2015.06.013
Estrogenic potential of progestins in oralcontraceptivesto stimulate human breast cancer cell proliferation, Cancer Research, vol.52, issue.23, pp.6539-6546, 1992. ,
SIGNIFICANCE TESTING OF SYNERGISTIC/ANTAGONISTIC, DOSE LEVEL???DEPENDENT, OR DOSE RATIO???DEPENDENT EFFECTS IN MIXTURE DOSE???RESPONSE ANALYSIS, Environmental Toxicology and Chemistry, vol.24, issue.10, pp.2701-2713, 2005. ,
DOI : 10.1897/04-431R.1
Ten Years of Mixing Cocktails: A Review of Combination Effects of Endocrine-Disrupting Chemicals, Environmental Health Perspectives, vol.115, issue.S-1, pp.98-105, 2007. ,
DOI : 10.1289/ehp.9357
The Challenge Presented by Progestins in Ecotoxicological Research: A Critical Review, Environmental Science & Technology, vol.49, issue.5, pp.2625-2638, 2015. ,
The metabolism of 19-nor contraceptive progestins modulates their biological activity at the neuroendocrine level, Journal of Steroid Biochemistry, vol.27, issue.4-6, pp.4-6, 1987. ,
DOI : 10.1016/0022-4731(87)90134-8
-acting element involved in cell-specific expression of the zebrafish brain aromatase gene, Molecular Reproduction and Development, vol.54, issue.10, pp.1549-1557, 2008. ,
DOI : 10.1128/MCB.6.8.2784
Assessment of Xenoestrogens Using Three Distinct Estrogen Receptors and the Zebrafish Brain Aromatase Gene in a Highly Responsive Glial Cell System, Environmental Health Perspectives, vol.114, issue.5, pp.752-758, 2006. ,
DOI : 10.1289/ehp.8141
URL : https://hal.archives-ouvertes.fr/hal-00068400
Comparison of in Vivo and in Vitro Reporter Gene Assays for Short-Term Screening of Estrogenic Activity, Environmental Science & Technology, vol.36, issue.20, pp.4410-4415, 2002. ,
DOI : 10.1021/es010323a
Mechanism of action of levonorgestrel: In vitro metabolism and specific interactions with steroid receptors in target organs, The Journal of Steroid Biochemistry and Molecular Biology, vol.41, issue.3-8, pp.3-8, 1992. ,
DOI : 10.1016/0960-0760(92)90442-L
Effects of binary mixtures of xenoestrogens on gonadal development and reproduction in zebrafish, Aquatic Toxicology, vol.80, issue.4, pp.382-395, 2006. ,
DOI : 10.1016/j.aquatox.2006.10.004
Occurrence, fate and removal of synthetic oral contraceptives (SOCs) in the natural environment: A review, Science of The Total Environment, vol.409, issue.24, pp.5149-5161, 2011. ,
DOI : 10.1016/j.scitotenv.2011.08.047
The problem of synergism and antagonism of combined drugs, Arzneimittelforschung, vol.3, issue.6, pp.285-290, 1953. ,
Molecular Characterization of Three Estrogen Receptor Forms in Zebrafish: Binding Characteristics, Transactivation Properties, and Tissue Distributions1, Biology of Reproduction, vol.98, issue.6, pp.1881-1892, 2002. ,
DOI : 10.1073/pnas.041617498
Identification of aromatase-positive radial glial cells as progenitor cells in the ventricular layer of the forebrain in zebrafish, The Journal of Comparative Neurology, vol.1334, issue.1, pp.150-167, 2007. ,
DOI : 10.1016/S0304-4165(96)00115-8
URL : https://hal.archives-ouvertes.fr/hal-00096389
Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals, Aquatic Toxicology, vol.138, issue.139, pp.88-97, 2013. ,
DOI : 10.1016/j.aquatox.2013.05.001
URL : https://hal.archives-ouvertes.fr/hal-00877351
Assessing combined toxicity of estrogen receptor agonists in a primary culture of rainbow trout (Oncorhynchus mykiss) hepatocytes, Aquatic Toxicology, vol.101, issue.1, pp.186-195, 2011. ,
DOI : 10.1016/j.aquatox.2010.09.018
R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing, 2014. ,
-Octylphenol Detected in the E-SCREEN Assay, Environmental Science & Technology, vol.38, issue.23, pp.6343-6352, 2004. ,
DOI : 10.1021/es049681e
Bioassays analysis usin R, Journal of Statistical Software, vol.12, issue.5, pp.1-22, 2005. ,
From single chemicals to mixtures ? reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow, Aquatic Toxicology, vol.169, pp.152-167, 2015. ,
Several Synthetic Progestins with Different Potencies Adversely Affect Reproduction of Fish, Environmental Science & Technology, vol.47, issue.4, pp.2077-2084, 2013. ,
DOI : 10.1021/es3048834
Mixture effects of levonorgestrel and ethinylestradiol: Estrogenic biomarkers and hormone receptor mRNA expression during sexual programming, Aquatic Toxicology, vol.161, pp.146-153, 2015. ,
DOI : 10.1016/j.aquatox.2015.02.004
Garcí a, I. Grillasca and A ,
Assessment of the oestrogenic activity of the contraceptive progestin levonorgestrel and its non-phenolic metabolites, European Journal of Pharmacology, vol.427, issue.2, pp.167-174, 2001. ,
Oestrogen reporter transgenic medaka for non-invasive evaluation of aromatase activity, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.179, pp.64-71, 2016. ,
DOI : 10.1016/j.cbpc.2015.08.011
), Environmental Science & Technology, vol.47, issue.4, pp.2043-2051, 2013. ,
DOI : 10.1021/es304305k
Environmental concentrations of an androgenic progestin disrupts the seasonal breeding cycle in male three-spined stickleback (Gasterosteus aculeatus), Aquatic Toxicology, vol.147, pp.84-91, 2014. ,
DOI : 10.1016/j.aquatox.2013.12.013
(aromatase B) transgenic zebrafish line that expresses GFP in radial glial cells, genesis, vol.1, issue.2, pp.67-73, 2009. ,
DOI : 10.1007/978-3-0348-8979-7
URL : https://hal.archives-ouvertes.fr/hal-00364893
Screening of pharmaceuticals and hormones at the regional scale, in surface and groundwaters intended to human consumption, Environmental Pollution, vol.159, issue.10, pp.2929-2934, 2011. ,
DOI : 10.1016/j.envpol.2011.04.033
Multi-residue analysis of steroids at sub-ng/L levels in surface and ground-waters using liquid chromatography coupled to tandem mass spectrometry, Journal of Chromatography A, vol.1210, issue.1, pp.84-91, 2008. ,
DOI : 10.1016/j.chroma.2008.09.034
URL : https://hal.archives-ouvertes.fr/hal-00509283
Mixtures of endocrine disruptors: How similar must mechanisms be for concentration addition to apply?, Toxicology, vol.313, issue.2-3, pp.129-133, 2013. ,
DOI : 10.1016/j.tox.2013.01.009
EFFECTS OF SYNTHETIC GESTAGENS ON FISH REPRODUCTION, Environmental Toxicology and Chemistry, vol.28, issue.12, pp.2663-2670, 2009. ,
DOI : 10.1897/08-485.1
) at Environmental Concentrations, Environmental Science & Technology, vol.46, issue.9, pp.5183-5192, 2012. ,
DOI : 10.1021/es300231y