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Journal articles
Prenatal exposure to chlordecone, gestational weight gain, and birth weight in a Guadeloupean birth cohort
Abstract : Background Chlordecone is a persistent organochlorine insecticide with well-defined estrogenic properties. It was intensively used in the French West Indies until 1993 to control the banana root borer. Because of the long-term contamination of soils and water, the population is currently exposed to chlordecone through food consumption. Chlordecone has been found in the blood of pregnant women and in cord blood. It has been shown to be an endocrine-disrupting chemical and exposure during pregnancy may affect fetal growth. Objectives The objective of our study was to examine the association between prenatal exposure to chlordecone and fetal growth based on the TIMOUN birth cohort conducted in Guadeloupe, with a focus on the potential modification of this relationship by maternal body mass index (BMI) and gestational weight gain (GWG). Methods Chlordecone was determined in cord plasma at birth in 593 babies. Birth weight was the indicator of fetal growth. Maternal pre-pregnancy BMI and GWG were determined. Adherence to GWG recommendations of the US Institute of Medicine based on maternal pre-pregnancy BMI was assessed. Birth weight was analyzed relative to cord blood chlordecone levels using linear and non-linear regression models. Results Overall chlordecone in cord blood was not associated with birth weight, but we found an interaction between chlordecone exposure with GWG and adherence to GWG recommendations. After stratification by GWG, we found a significant U-shaped association between birth weight and chlordecone exposure, within the upper quartiles of GWG or excessive GWG. Conclusion Chlordecone exposure may affect fetal growth, particularly when excessive GWG is present. © 2016 Elsevier Inc.
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367154
Contributor : Xavier Chard-Hutchinson <>
Submitted on : Thursday, September 15, 2016 - 4:46:13 PM
Last modification on : Tuesday, March 3, 2020 - 5:18:37 PM
Contributor : Xavier Chard-Hutchinson <>
Submitted on : Thursday, September 15, 2016 - 4:46:13 PM
Last modification on : Tuesday, March 3, 2020 - 5:18:37 PM