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Cyaneodimycin, a Bioactive Compound Isolated from the Culture of Streptomyces cyaneofuscatus Associated with Lichina confinis

Abstract : Two new compounds, cyaneodimycin (1) and cyaneomycin (2) bearing a rare methacrylate residue, were isolated from cultures of the bacterium Streptomyces cyaneofuscatus associated with the marine lichen Lichina confinis. These astonishing structures may be derived from a pyruvate biosynthetic pathway. Cyaneodimycin (1) exhibited antiproliferative properties against B16 (IC50= 27 ± 4 µm), HaCaT (IC50= 47 ± 11 µm) and Jurkat cell lines (IC50= 18.5 ± 0.5 µm). Six known compounds 3–8 with diversified structures and interesting biological properties (diketopiperazines, actinomycin, dibenzofurane or indole derivatives) were isolated jointly with compounds 1 and 2. Among them, usnic acid (8), a common lichen compound was isolated for the first time from bacteria. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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D. Parrot, N. Legrave, L. Intertaglia, I. Rouaud, P. Legembre, et al.. Cyaneodimycin, a Bioactive Compound Isolated from the Culture of Streptomyces cyaneofuscatus Associated with Lichina confinis. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2016, 2016 (23), pp.3977--3982. ⟨10.1002/ejoc.201600252⟩. ⟨hal-01367206⟩

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