Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation

D. Best; M. Jean; P. van de Weghe

doi:10.1021/acs.joc.6b01426

Journal articles

Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation

D. Best ¹ M. Jean ¹ P. van de Weghe ¹

1 ISCR - Institut des Sciences Chimiques de Rennes

Abstract : One-pot formation of arylacetic acid esters, thioesters, and amides via Rh(II)-catalyzed arylation of a Meldrum's acid-derived diazo reagent with electron-rich arenes is described. The methodology was used to efficiently synthesize an anticancer compound. © 2016 American Chemical Society.

Keywords : Aromatic compounds Modular synthesis Meldrum's acids Amides Catalysis Diazo reagents Esters Rhodium Anticancer compounds Aryl ether Arylacetic acids Chemical reactions Arylations Electron-rich arenes

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Journal articles

Domain :

Chemical Sciences

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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367227
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Submitted on : Thursday, September 15, 2016 - 5:17:32 PM
Last modification on : Wednesday, January 13, 2021 - 3:12:42 AM

Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation

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Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation

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