Behavioral Effects of an Antiandrogen in Adult Male Rhesus Macaques (Macaca mulatta)

Bertrand L. Deputte (1) , J. Johnson (2) , M. Hempel (2) , G. Scheffeler (2)

1 URA373 Laboratoire d'Ethologie [Ontogenèse et valeur adaptative des comportements]
2 Wisconsin Regional Primate Research Center

This study was designed to determine how to suppress behavioral effects of androgens with a pure non-steroidal antiandrogen, Hydroxyflutamide (OHF). The major dependent variable was yawning behavior of castrated adult male rhesus macaques. Injections of testosterone propionate (TP) increased yawning frequency and cessation of TP injections produced a decrease in yawning frequency. A similar decrease was observed with simultaneous injections of TP and OHF. It has been found that the dose of O/HF injected subcutaneously should be 80 times that of TP to block the effects of either physiological or supraphysiological doses of TP.

Domaines: Sciences du Vivant [q-bio]; Biologie animale

Bertrand L. Deputte, J. Johnson, M. Hempel, G. Scheffeler. Behavioral Effects of an Antiandrogen in Adult Male Rhesus Macaques (Macaca mulatta). Hormones and Behavior, 1994, 28 (2), pp.155-164. ⟨10.1006/hbeh.1994.1013⟩. ⟨hal-01368787⟩