Synchronization and Registration of Cine Magnetic Resonance and Dynamic Computed Tomography Images of the Heart

J. Betancur (1) , A. Simon (2, 1) , B. Langella (3) , Christophe Leclercq (1, 3) , A. Hernandez (3, 1) , M. Garreau (1)

1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 CHU Pitié-Salpêtrière [AP-HP]
3 Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes]

The synchronization and registration of dynamic computed tomography (CT) and magnetic resonance images (MRI) of the heart is required to perform a combined analysis of their complementary information. We propose a novel method that synchronizes and registers intrapatient dynamic CT and cine-MRI short axis view (SAX). For the synchronization step, a normalized cross-correlation curve is computed from each image sequence to describe the global cardiac dynamics. The time axes of these curves are then warped using an adapted dynamic time warping (DTW) procedure. The adaptation constrains the time deformation to obtain a coherent warping function. The registration step then computes the rigid transformation that maximizes the multiimage normalized mutual information of DTW-synchronized images. The DTW synchronization and the multiimage registration were evaluated using dynamic CT and cine-SAX acquisitions from nine patients undergoing cardiac resynchronization therapy. The distance between the end-systolic phases after DTW was used to evaluate the synchronization. Mean errors, expressed as a percentage of the RR-intervals, were 3.9% and 3.7% after adapted DTW synchronization against 10.8% and 11.3% after linear synchronization, for dynamic CT and cine-SAX, respectively. This suggests that the adapted DTW synchronization leads to a coherent warping of cardiac dynamics. The multiimage registration was evaluated using fiducial points. Compared to a monoimage and a two-image registration, the multiimage registration of DTW-synchronized images obtained the lowest mean fiducial error showing that the use of dynamic voxel intensity information improves the registration. © 2015 IEEE.

Keywords: Cardiac resynchronization therapy; Image registration; Magnetic resonance imaging; Magnetism; Patient treatment; Resonance; Synchronization; Tomography; Cardiac resynchronization therapy (CRT); Computed tomography images; Dynamic time warping; Magnetic resonance images (MRI); Multi-image registrations; Normalized cross correlation; Normalized mutual information; Rigid transformations; Computerized tomography; cine magnetic resonance imaging; clinical article; computer assisted tomography; error; heart; human; image analysis; registration; RR interval

Domains: Life Sciences [q-bio]; Bioengineering

J. Betancur, A. Simon, B. Langella, Christophe Leclercq, A. Hernandez, et al.. Synchronization and Registration of Cine Magnetic Resonance and Dynamic Computed Tomography Images of the Heart. IEEE Journal of Biomedical and Health Informatics, 2016, 20 (5), pp.1369--1376. ⟨10.1109/JBHI.2015.2453639⟩. ⟨hal-01372354⟩