Cytokines down-regulate expression of major cytochrome P- 450 enzymes in adult human hepatocytes in primary culture, Mol Pharmacol, vol.44, pp.707-715, 1993. ,
Nonsteroidal Anti-Inflammatory Drug???Induced Hepatotoxicity, Clinics in Liver Disease, vol.11, issue.3, pp.563-575, 2007. ,
DOI : 10.1016/j.cld.2007.06.004
EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS, Drug Metabolism and Disposition, vol.34, issue.1, pp.75-83, 2006. ,
DOI : 10.1124/dmd.105.006759
URL : https://hal.archives-ouvertes.fr/hal-00702085
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells, Hepatology, vol.35, issue.4, pp.1518-1529, 2013. ,
DOI : 10.1002/hep.26160
URL : https://hal.archives-ouvertes.fr/hal-00865999
Interactions of glutathione S-transferase-pi with ethacrynic acid and its glutathione conjugate, 1993. ,
Impact of Inflammation on Chlorpromazine-Induced Cytotoxicity and Cholestatic Features in HepaRG Cells, Drug Metabolism and Disposition, vol.42, issue.9, pp.1556-1566, 2014. ,
DOI : 10.1124/dmd.114.058123
URL : https://hal.archives-ouvertes.fr/hal-01134764
Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes, Toxicological Sciences, vol.145, issue.1, pp.157-168, 2015. ,
DOI : 10.1093/toxsci/kfv041
URL : https://hal.archives-ouvertes.fr/hal-01134682
Diclofenac-associated hepatotoxicity: Analysis of 180 cases reported to the food and drug administration as adverse reactions, Hepatology, vol.12, issue.3, pp.820-827, 1995. ,
DOI : 10.1002/hep.1840220320
Suspected drug-induced liver fatalities reported to the WHO database, Digestive and Liver Disease, vol.38, issue.1, pp.33-38, 2006. ,
DOI : 10.1016/j.dld.2005.06.004
Glutathione transferases, regulators of cellular metabolism and physiology, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1830, issue.5, pp.3267-3288, 2013. ,
DOI : 10.1016/j.bbagen.2012.11.019
Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity, J Pharmacol Exp Ther, vol.288, pp.65-72, 1999. ,
Fatal hepatitis associated with diclofenac., Gut, vol.27, issue.11, pp.1390-1393, 1986. ,
DOI : 10.1136/gut.27.11.1390
Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor, Hepatology, vol.103, issue.4, pp.957-967, 2007. ,
DOI : 10.1002/hep.21536
URL : https://hal.archives-ouvertes.fr/hal-00690471
Acute and clinically relevant drug-induced liver injury: a population based case-control study, British Journal of Clinical Pharmacology, vol.19, issue.1, pp.71-80, 2004. ,
DOI : 10.1111/j.1572-0241.2002.05505.x
Modest inflammation enhances, 2006. ,
Liver Protection from Apoptosis Requires Both Blockage of Initiator Caspase Activities and Inhibition of ASK1/JNK Pathway via Glutathione S-Transferase Regulation, Journal of Biological Chemistry, vol.277, issue.51, pp.49220-49229, 2002. ,
DOI : 10.1074/jbc.M207325200
Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS, Biochemical Pharmacology, vol.66, issue.11, pp.2155-2167, 2003. ,
DOI : 10.1016/j.bcp.2003.08.003
Diclofenac induces apoptosis in hepatocytes, Toxicology in Vitro, vol.17, issue.5-6, pp.675-680, 2003. ,
DOI : 10.1016/S0887-2333(03)00105-X
High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver, Cell Biology International Reports, vol.6, issue.6, pp.625-628, 1982. ,
DOI : 10.1016/0309-1651(82)90187-4
toxicology, Expert Opinion on Drug Metabolism & Toxicology, vol.114, issue.10, pp.1279-1294, 2008. ,
DOI : 10.1126/science.1151526
URL : https://hal.archives-ouvertes.fr/hal-00742183
Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death, Free Radical Biology and Medicine, vol.31, issue.2, pp.139-152, 2001. ,
DOI : 10.1016/S0891-5849(01)00560-3
Diclofenac Covalent Protein Binding Is Dependent on Acyl Glucuronide Formation and Is Inversely Related to P450-Mediated Acute Cell Injury in Cultured Rat Hepatocytes, Toxicology and Applied Pharmacology, vol.120, issue.1, pp.155-161, 1993. ,
DOI : 10.1006/taap.1993.1097
Bid Truncation, Bid/Bax Targeting to the Mitochondria, and Caspase Activation Associated with Neutrophil Apoptosis Are Inhibited by Granulocyte Colony-Stimulating Factor, The Journal of Immunology, vol.172, issue.11, pp.7024-7030, 2004. ,
DOI : 10.4049/jimmunol.172.11.7024
Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats, Hepatology, vol.57, issue.3, pp.544-551, 2002. ,
DOI : 10.1053/jhep.2002.31871
Nephrotoxic cell death by diclofenac and meloxicam, Biochemical and Biophysical Research Communications, vol.369, issue.3, pp.873-877, 2008. ,
DOI : 10.1016/j.bbrc.2008.02.116
Measuring ER Stress and the Unfolded Protein Response Using Mammalian Tissue Culture System, Methods in enzymology, vol.490, pp.71-92, 2011. ,
DOI : 10.1016/B978-0-12-385114-7.00004-0
Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye, Toxicology and Applied Pharmacology, vol.254, issue.3, pp.256-266, 2011. ,
DOI : 10.1016/j.taap.2011.04.018
URL : https://hal.archives-ouvertes.fr/hal-00740177
Role of drug-independent stress factors in liver injury associated with diclofenac intake, Toxicology, vol.312, pp.83-96, 2013. ,
DOI : 10.1016/j.tox.2013.08.002
Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells, Drug Metabolism and Disposition, vol.40, issue.1, pp.151-158, 2012. ,
DOI : 10.1124/dmd.111.042028
URL : https://hal.archives-ouvertes.fr/hal-00865978
[Acute renal failure and nephrotic syndrome associated with treatment with diclofenac], Rev Clin Esp, vol.191, pp.289-290, 1992. ,
Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats, Gastroenterology, vol.115, issue.6, pp.1476-1482, 1998. ,
DOI : 10.1016/S0016-5085(98)70026-5
Different Dose-Dependent Mechanisms Are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells, Toxicological Sciences, vol.141, issue.1, pp.244-253, 2014. ,
DOI : 10.1093/toxsci/kfu122
URL : https://hal.archives-ouvertes.fr/hal-01016342
Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01326368
Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes, Toxicological Sciences, vol.147, issue.2, pp.573-587, 2015. ,
DOI : 10.1093/toxsci/kfv155
URL : https://hal.archives-ouvertes.fr/hal-01187306
Pathogenesis of diclofenac enteropathy, Gastroenterology, vol.120, issue.7, pp.1886-1887, 1885. ,
DOI : 10.1053/gast.2001.25307
Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin ??6??4-dependent Akt, GSK-3??, and HSF-1 in mesenchymal stem cells, Cell Death and Disease, vol.16, issue.3, p.563, 2013. ,
DOI : 10.1002/jcp.24084
Evaluation of Which Reactive Metabolite, If Any, Is Responsible for a Specific Idiosyncratic Reaction, Drug Metabolism Reviews, vol.213, issue.4, pp.745-753, 2006. ,
DOI : 10.1172/JCI3544
Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis, Hepatol Res, vol.37, pp.598-607, 2007. ,
CMZ Reversed Chronic Ethanol-Induced Disturbance of PPAR-?? Possibly by Suppressing Oxidative Stress and PGC-1?? Acetylation, and Activating the MAPK and GSK3?? Pathway, PLoS ONE, vol.5, issue.6, p.98658, 2014. ,
DOI : 10.1371/journal.pone.0098658.s001
Role of Intestinal Cytochrome P450 Enzymes in Diclofenac-Induced Toxicity in the Small Intestine, Journal of Pharmacology and Experimental Therapeutics, vol.343, issue.2, pp.362-370, 2012. ,
DOI : 10.1124/jpet.112.198077