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Multimodal therapy including yttrium-90 radioembolization as a bridging therapy to liver transplantation for a huge and locally advanced intrahepatic cholangiocarcinoma

Abstract : Treatment of intrahepatic cholangiocarcinoma remains a major challenge. For an unresectable lesion without extrahepatic spread, liver transplantation could be a potential solution but it is still associated with poor oncologic results owing to the absence of effective neoadjuvant treatment. We report the case of a young man with locally advanced intrahepatic cholangiocarcinoma presenting with multiple intrahepatic metastases and vascular structure involvement. The lesion was significantly downstaged by a multimodal therapy including intra-arterial Yttrium-90 radioembolization, systemic chemotherapy and external radiotherapy, allowing liver transplantation. Three years after the procedure, oncologic outcome is excellent with no sign of recurrence. Multimodal therapy including Yttrium-90 radioembolization could be relevant as neoadjuvant treatment before liver transplantation for unresectable intrahepatic cholangiocarcinoma. © 2016, Romanian Society of Gastroenterology. All rights reserved.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01373302
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, September 28, 2016 - 2:54:44 PM
Last modification on : Monday, January 13, 2020 - 10:23:40 AM

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M. Rayar, G.B. Levi Sandri, P. Houssel-Debry, C. Camus, L. Sulpice, et al.. Multimodal therapy including yttrium-90 radioembolization as a bridging therapy to liver transplantation for a huge and locally advanced intrahepatic cholangiocarcinoma. Journal of Gastrointestinal and Liver Diseases, Romanian Societies of Gastroenterology, 2016, 25 (3), pp.401--404. ⟨10.15403/jgld.2014.1121.253.y90⟩. ⟨hal-01373302⟩

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