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Low-Intensity Local Direct Current modulates interictal discharges in mTLE: computational and experimental insights

Faten Mina 1 Pascal Benquet 1 Gabriel Dieuset 1 Fabrice Wendling 1
1 LTSI - Laboratoire Traitement du Signal et de l'Image
Abstract : Low intensity Local Direct Current Stimulation (LDCS) is an electrical stimulation technique that has been poorly investigated in vivo in the field of epilepsy. This study addresses the computational as well as the experimental in vivo effects of low intensity DC stimulation currents on Hippocampal Paroxysmal Discharges (HPDs), a common form of interictal discharges in mesial temporal lobe epilepsy. The results highlight the significance of polarity-dependent effects in silico as well as in freely moving epileptic mice. In conclusion, this combined in silico- in vivo approach shows that cathodal LDCS can significantly reduce the occurrence of HPDs.
Keywords : polarization impedance stimulation models seizures signals spikes
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Conference papers
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01380106
Contributor : Laurent Jonchère <>
Submitted on : Wednesday, October 12, 2016 - 2:57:59 PM
Last modification on : Wednesday, May 16, 2018 - 11:23:41 AM

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  • HAL Id : hal-01380106, version 1

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UNIV-RENNES1 | LTSI | UNIV-RENNES

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Faten Mina, Pascal Benquet, Gabriel Dieuset, Fabrice Wendling. Low-Intensity Local Direct Current modulates interictal discharges in mTLE: computational and experimental insights. 7th Annual International IEEE EMBS Conference on Neural Engineering (NER), Apr 2015, Montpellier, France. pp.878--881. ⟨hal-01380106⟩

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