Low-Intensity Local Direct Current modulates interictal discharges in mTLE: computational and experimental insights

Abstract : Low intensity Local Direct Current Stimulation (LDCS) is an electrical stimulation technique that has been poorly investigated in vivo in the field of epilepsy. This study addresses the computational as well as the experimental in vivo effects of low intensity DC stimulation currents on Hippocampal Paroxysmal Discharges (HPDs), a common form of interictal discharges in mesial temporal lobe epilepsy. The results highlight the significance of polarity-dependent effects in silico as well as in freely moving epileptic mice. In conclusion, this combined in silico- in vivo approach shows that cathodal LDCS can significantly reduce the occurrence of HPDs.