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Fluorous supported synthesis of pyrazolone derivatives from allylic alcohols using a palladium-catalyzed strategy

Abstract : Ten substituted pyrazolone derivatives were easily synthesized from perfluorinated allylic alcohols, via a straightforward two steps reaction involving a Heck-coupling/isomerization reaction and subsequent condensation of hydrazines. This fluorous supported methodology, that combines a cyclo-release approach and F-SPE purification allows for the obtaining of the final products with a good purity.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-01381125
Contributor : Laurent Jonchère <>
Submitted on : Friday, October 14, 2016 - 9:18:23 AM
Last modification on : Tuesday, September 8, 2020 - 3:10:12 AM

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N. Gouault, A. Cariou, J.-F. Cupif, P. de Aguiar Amaral, M. David. Fluorous supported synthesis of pyrazolone derivatives from allylic alcohols using a palladium-catalyzed strategy. Química Nova, Sociedade Brasileira de Química, 2016, 39, pp.825--831. ⟨10.5935/0100-4042.20160098⟩. ⟨hal-01381125⟩

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